Os I, Kjeldsen S E, Westheim A, Lande K, Norman N, Hjermann I, Eide I
Scand J Clin Lab Invest. 1987 Jun;47(4):371-7.
Hormonal, mean arterial blood pressure, forearm blood flow and heart rate responses to graded dopamine infusion (0.5-2.0 micrograms/kg/min) were examined in 10 men with untreated essential hypertension WHO group I (147 +/- 4/100 +/- 1 mmHg, means +/- SE), and in 10 normotensive men (129 +/- 2/85 +/- 1 mmHg), all 40 years old. Another 12 normotensive men (126 +/- 3/80 +/- 2 mmHg) were given only saline infusion. Dopamine increased heart rate significantly in the hypertensive group (8 +/- 2 beats/min, p less than 0.001), but the heart rate remained unchanged in the normotensive group (1 +/- 1 beats/min, NS). Although dopamine infusion tended to decrease mean blood pressure, the changes were not significantly different from those observed in the control group. No change in forearm blood flow was observed in either group. In the groups given dopamine, prolactin levels decreased only slightly compared to the control group given saline, the decrement tending to be more pronounced in the hypertensive group. Plasma vasopressin remained unchanged in both groups during dopamine infusion. These results indicate that hypertensive patients exhibit increased sensitivity to the cardiovascular effects of dopamine.
对10名未经治疗的世界卫生组织I组原发性高血压男性患者（平均动脉血压为147±4/100±1 mmHg，均值±标准误）和10名血压正常的40岁男性（平均动脉血压为129±2/85±1 mmHg），研究了分级输注多巴胺（0.5 - 2.0微克/千克/分钟）时激素、平均动脉血压、前臂血流量和心率的反应。另外12名血压正常的男性（平均动脉血压为126±3/80±2 mmHg）仅输注生理盐水。多巴胺使高血压组的心率显著增加（8±2次/分钟，p<0.001），而血压正常组的心率保持不变（1±1次/分钟，无显著性差异）。尽管输注多巴胺倾向于降低平均血压，但与对照组相比，变化无显著差异。两组的前臂血流量均未观察到变化。在输注多巴胺的组中，与输注生理盐水的对照组相比，催乳素水平仅略有下降，高血压组的下降趋势更明显。在输注多巴胺期间，两组的血浆血管加压素均保持不变。这些结果表明，高血压患者对多巴胺的心血管效应表现出更高的敏感性。
