Al-Seeni Madeha N, El Rabey Haddad A, Al-Solamy Suad M
Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia Genetic Engineering and Biotechnology Institute, Sadat City University, Sadat, Minufiya, Egypt
Toxicol Ind Health. 2015 Jun;31(6):485-93. doi: 10.1177/0748233714551765. Epub 2014 Sep 25.
This study aimed to test the protective role of natural bee honey against melamine toxicity in the kidney of male albino rats. The dietary supplementation of melamine at a dose of 20,000 ppm for 28 days induced renal dysfunction, as reflected by a significant increase in kidney function parameters (urea, creatinine, and uric acid) and an increase in potassium levels. In addition, a decrease in catalase and glutathione-S-transferase and an increase in lipid peroxide in the kidney tissue homogenate were also observed. Histological changes in the melamine-treated group revealed hyperplasia and damage in kidney cells and the accumulation of melamine crystals in kidney tissues. Honey treatment for 28 days in rats concurrently administered melamine at a dose of 2.5 g/kg body weight for 28 days improved the kidney function, increased antioxidant enzymes, and decreased lipid peroxide levels. The morphology of the kidney cells of the melamine-fed rats was also improved as a result of honey treatment. In conclusion, this study revealed that natural bee honey protects the kidney against the adverse effects induced by melamine toxicity in male albino rats.
本研究旨在测试天然蜂蜜对雄性白化大鼠肾脏中三聚氰胺毒性的保护作用。以20000 ppm的剂量在饮食中补充三聚氰胺28天会导致肾功能障碍，这表现为肾功能参数（尿素、肌酐和尿酸）显著增加以及钾水平升高。此外，还观察到肾脏组织匀浆中过氧化氢酶和谷胱甘肽 - S - 转移酶减少以及脂质过氧化物增加。三聚氰胺处理组的组织学变化显示肾细胞增生和损伤以及三聚氰胺晶体在肾脏组织中的积累。在以2.5 g/kg体重的剂量同时给予三聚氰胺28天的大鼠中，用蜂蜜处理28天改善了肾功能，增加了抗氧化酶，并降低了脂质过氧化物水平。蜂蜜处理还改善了喂食三聚氰胺的大鼠肾细胞的形态。总之，本研究表明天然蜂蜜可保护雄性白化大鼠的肾脏免受三聚氰胺毒性引起的不良影响。
