Weissig Volkmar, Pettinger Tracy K, Murdock Nicole
Department of Pharmaceutical Sciences, Midwestern University College of Pharmacy Glendale, Glendale, AZ, USA.
Department of Pharmacy Practice and Administrative Sciences, College of Pharmacy, Idaho State University, Pocatello, ID, USA.
Int J Nanomedicine. 2014 Sep 15;9:4357-73. doi: 10.2147/IJN.S46900. eCollection 2014.
In 2000, the National Institute of Health launched the National Nanotechnology Initiative to support, coordinate, and advance research and development of nanoscale projects. The impact of this new program on health-science related research and development became quickly visible. Broad governmental financial support advanced the start of new, and the deepening of already existing, interdisciplinary research. The anticipated merger of nanoscience with medicine quickly instigated the conceptualization of nanomedicine. The adoption of nanoscience terminology by pharmaceutical scientists resulted in the advent of nanopharmaceuticals. The term "nano" became tantamount to "cutting-edge" and was quickly embraced by the pharmaceutical science community. Colloidal drug delivery systems reemerged as nanodrug delivery systems; colloidal gold became a suspension of nano gold particles. In this review, we first review nanoscience related definitions applied to pharmaceuticals, we then discuss all 43 currently approved drug formulations which are publicized as nanopharmaceuticals, and finally we analyze clinical aspects of selected drug formulations.
2000年，美国国立卫生研究院发起了国家纳米技术计划，以支持、协调和推进纳米级项目的研发。这一新计划对健康科学相关研发的影响很快显现出来。政府的广泛财政支持推动了新的跨学科研究的启动以及现有跨学科研究的深化。纳米科学与医学的预期融合迅速催生了纳米医学的概念。制药科学家采用纳米科学术语导致了纳米药物的出现。“纳米”一词等同于“前沿”，并很快被制药科学界所接受。胶体药物递送系统重新成为纳米药物递送系统；胶体金变成了纳米金颗粒的悬浮液。在本综述中，我们首先回顾适用于药物的纳米科学相关定义，然后讨论目前公布的所有43种被宣传为纳米药物的已批准药物制剂，最后分析所选药物制剂的临床方面。
