Mohamad Farook Nurul Amirah, Argimón Silvia, Abdul Samat Muttaqillah Najihan, Salleh Sharifah Azura, Sulaiman Sunita, Tan Toh Leong, Periyasamy Petrick, Lau Chee Lan, Ismail Zalina, Muhammad Azami Nor Azila, Ang Mia Yang, Neoh Hui-Min
UKM Medical Molecular Biology Research Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford OX3 7LE, UK.
Trop Med Infect Dis. 2022 Dec 13;7(12):438. doi: 10.3390/tropicalmed7120438.
Methicillin-resistant (MRSA) is a successful pathogen that has achieved global dissemination, with high prevalence rates in Southeast Asia. A huge diversity of clones has been reported in this region, with MRSA ST239 being the most successful lineage. Nonetheless, description of MRSA genotypes circulating in the Southeast Asia region has, until now, remained poorly compiled. In this review, we aim to provide a better understanding of the molecular epidemiology and distribution of MRSA clones in 11 Southeast Asian countries: Singapore, Malaysia, Thailand, Vietnam, Cambodia, Lao People's Democratic Republic (PDR), Myanmar, Philippines, Indonesia, Brunei Darussalam, and Timor-Leste. Notably, while archaic multidrug-resistant hospital-associated (HA) MRSAs, such as the ST239-III and ST241-III, were prominent in the region during earlier observations, these were then largely replaced by the more antibiotic-susceptible community-acquired (CA) MRSAs, such as ST22-IV and PVL-positive ST30-IV, in recent years after the turn of the century. Nonetheless, reports of livestock-associated (LA) MRSAs remain few in the region.
耐甲氧西林金黄色葡萄球菌（MRSA）是一种传播至全球的成功病原体，在东南亚地区的流行率很高。该地区已报告了种类繁多的克隆菌株，其中MRSA ST239是最成功的谱系。尽管如此，到目前为止，对东南亚地区流行的MRSA基因型的描述仍然缺乏完整的汇编。在本综述中，我们旨在更好地了解11个东南亚国家（新加坡、马来西亚、泰国、越南、柬埔寨、老挝人民民主共和国、缅甸、菲律宾、印度尼西亚、文莱达鲁萨兰国和东帝汶）MRSA克隆菌株的分子流行病学和分布情况。值得注意的是，在早期观察中，诸如ST239-III和ST241-III等古老的多重耐药医院相关（HA）MRSA在该地区较为突出，但在世纪之交后的近年来，这些菌株在很大程度上被更易被抗生素治疗的社区获得性（CA）MRSA所取代，如ST22-IV和PVL阳性的ST30-IV。尽管如此，该地区与牲畜相关（LA）的MRSA报告仍然很少。
