Ichii Michiko, Oritani Kenji, Kanakura Yuzuru
Michiko Ichii, Kenji Oritani, Yuzuru Kanakura, Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
World J Stem Cells. 2014 Sep 26;6(4):421-31. doi: 10.4252/wjsc.v6.i4.421.
B lymphocytes differentiate from hematopoietic stem cells through a series of distinct stages. Early B cell development proceeds in bone marrow until immature B cells migrate out to secondary lymphoid tissues, such as a spleen and lymph nodes, after completion of immunoglobulin heavy and light chain rearrangement. Although the information about the regulation by numerous factors, including signaling molecules, transcription factors, epigenetic changes and the microenvironment, could provide the clinical application, our knowledge on human B lymphopoiesis is limited. However, with great methodological advances, significant progress for understanding B lymphopoiesis both in human and mouse has been made. In this review, we summarize the experimental models for studies about human adult B lymphopoiesis, and the role of microenvironment and signaling molecules, such as cytokines, transforming growth factor-β superfamily, Wnt family and Notch family, with point-by-point comparison between human and mouse.
B淋巴细胞通过一系列不同阶段从造血干细胞分化而来。早期B细胞发育在骨髓中进行，直到免疫球蛋白重链和轻链重排完成后，未成熟B细胞迁移到二级淋巴组织，如脾脏和淋巴结。尽管关于包括信号分子、转录因子、表观遗传变化和微环境在内的众多因素的调控信息可用于临床应用，但我们对人类B淋巴细胞生成的了解仍然有限。然而，随着方法学的巨大进步，在理解人类和小鼠的B淋巴细胞生成方面都取得了重大进展。在这篇综述中，我们总结了用于研究人类成人B淋巴细胞生成的实验模型，以及微环境和信号分子（如细胞因子、转化生长因子-β超家族、Wnt家族和Notch家族）的作用，并对人类和小鼠进行了逐点比较。
