普通人群的非增强全身磁共振成像：50岁及以下患者与老年受试者异常发现的发生率比较。
Non-contrast-enhanced whole-body magnetic resonance imaging in the general population: the incidence of abnormal findings in patients 50 years old and younger compared to older subjects.
作者信息
Cieszanowski Andrzej, Maj Edyta, Kulisiewicz Piotr, Grudzinski Ireneusz P, Jakoniuk-Glodala Karolina, Chlipala-Nitek Irena, Kaczynski Bartosz, Rowinski Olgierd
机构信息
2nd Department of Clinical Radiology, Medical University of Warsaw, Warsaw, Poland; Diagnostic Center, Medicover Hospital, Warsaw, Poland.
Department of Toxicology, Medical University of Warsaw, Faculty of Pharmacy, Warsaw, Poland.
出版信息
PLoS One. 2014 Sep 26;9(9):e107840. doi: 10.1371/journal.pone.0107840. eCollection 2014.
PURPOSE
To assess and compare the incidence of abnormal findings detected during non-contrast-enhanced whole-body magnetic resonance imaging (WB-MRI) in the general population in two age groups: (1) 50 years old and younger; and (2) over 50 years old.
MATERIALS AND METHODS
The analysis included 666 non-contrast-enhanced WB-MRIs performed on a 1.5-T scanner between December 2009 and June 2013 in a private hospital in 451 patients 50 years old and younger and 215 patients over 50 years old. The following images were obtained: T2-STIR (whole body-coronal plane), T2-STIR (whole spine-sagittal), T2-TSE with fat-saturation (neck and trunk-axial), T2-FLAIR (head-axial), 3D T1-GRE (thorax-coronal, axial), T2-TSE (abdomen-axial), chemical shift (abdomen-axial). Detected abnormalities were classified as: insignificant (type I), potentially significant, requiring medical attention (type II), significant, requiring treatment (type III).
RESULTS
There were 3375 incidental findings depicted in 659 (98.9%) subjects: 2997 type I lesions (88.8%), 363 type II lesions (10.8%) and 15 type III lesions (0.4%), including malignant or possibly malignant lesions in seven subjects. The most differences in the prevalence of abnormalities on WB-MRI between patients 50 years old and younger and over 50 years old concerned: brain infarction (22.2%, 45.0% respectively), thyroid cysts/nodules (8.7%, 18.8%), pulmonary nodules (5.0%, 16.2%), significant degenerative disease of the spine (23.3%, 44.5%), extra-spinal degenerative disease (22.4%, 61.1%), hepatic steatosis (15.8%, 24.9%), liver cysts/hemangiomas (24%, 34.5%), renal cysts (16.9%, 40.6%), prostate enlargement (5.1% of males, 34.2% of males), uterine fibroids (16.3% of females, 37.9% of females).
CONCLUSIONS
Incidental findings were detected in almost all of the subjects. WB-MRI demonstrated that the prevalence of the vast majority of abnormalities increases with age.
目的
评估并比较在两个年龄组普通人群中，非增强全身磁共振成像（WB-MRI）检查时发现的异常情况的发生率：（1）50岁及以下；（2）50岁以上。
材料与方法
分析了2009年12月至2013年6月期间，在一家私立医院使用1.5-T扫描仪对451例50岁及以下患者和215例50岁以上患者进行的666例非增强WB-MRI检查。获取了以下图像：T2-STIR（全身冠状面）、T2-STIR（全脊柱矢状面）、脂肪饱和T2-TSE（颈部和躯干横断面）、T2-FLAIR（头部横断面）、3D T1-GRE（胸部冠状面、横断面）、T2-TSE（腹部横断面）、化学位移成像（腹部横断面）。检测到的异常分为：无意义（I型）、可能有意义，需要医疗关注（II型）、有意义，需要治疗（III型）。
结果
659名（98.9%）受试者中有3375项偶然发现：2997项I型病变（88.8%）、363项II型病变（10.8%）和15项III型病变（0.4%），其中包括7名受试者中的恶性或可能恶性病变。50岁及以下患者与50岁以上患者在WB-MRI上异常发生率的最大差异在于：脑梗死（分别为22.2%、45.0%）、甲状腺囊肿/结节（8.7%、18.8%）、肺结节（5.0%、16.2%）、脊柱严重退行性疾病（23.3%、44.5%）、脊柱外退行性疾病（22.4%、61.1%）、肝脂肪变性（15.8%、24.9%）、肝囊肿/血管瘤（24%、34.5%）、肾囊肿（16.9%、40.6%）、前列腺增生（男性中的5.1%、男性中的34.2%）、子宫肌瘤（女性中的16.3%、女性中的37.9%）。
结论
几乎所有受试者都检测到了偶然发现。WB-MRI表明，绝大多数异常的发生率随年龄增长而增加。
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