角叉菜烯 A：来自甲藻 Dinophysis acuminata 的新型聚醚大环内酯的结构和生物活性。

Acuminolide A: structure and bioactivity of a new polyether macrolide from dinoflagellate Dinophysis acuminata.

机构信息

Department of Marine Biotechnology, Kunsan National University , Jeonbuk, 573-701, South Korea.

出版信息

Org Lett. 2014 Oct 17;16(20):5362-5. doi: 10.1021/ol502567g. Epub 2014 Sep 26.

Abstract

Acuminolide A (1), along with pectenotoxin II (PTX-2), dinophysistoxin I (DTX-1), okadaic acid (OA), and 7-epi-PTX-2 seco acid, was isolated from a large-scale cultivation of the dinoflagellate Dinophysis acuminata. The new 33-membered macrolide 1 was characterized by detailed analysis of 2D NMR and MS data. Its relative stereochemistry was elucidated on the basis of ROESY correlations and J-based analysis. In contrast to the other well-known toxins that were isolated, 1 showed no cytotoxicity against four cancer cell lines but caused potent stimulation of actomyosin ATPase activity.

摘要

从大型培养的菱形藻(Dinophysis acuminata)中分离得到了尖吻螺内酯 A(1)，以及石房蛤毒素 II(PTX-2)、原甲藻毒素 I(DTX-1)、雪卡毒素(OA)和 7-表-PTX-2 脱酸。新的 33 元大环内酯 1 通过二维 NMR 和 MS 数据的详细分析进行了表征。根据 ROESY 相关和基于 J 的分析，阐明了其相对立体化学。与其他分离得到的著名毒素不同，1 对四种癌细胞系没有细胞毒性，但对肌球蛋白 ATP 酶活性有强烈的刺激作用。