Parmar Dixit, Rueping Magnus
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Chem Commun (Camb). 2014 Nov 21;50(90):13928-31. doi: 10.1039/c4cc05027d.
A mild intramolecular fluoro-cyclisation reaction of benzylic alcohols and amines has been developed. This strategy uses commercially available Selectfluor to trigger electrophilic cyclisations to afford fluorinated heterocycles containing 1,3-disubstitution. The dual role of the reagent as a fluorine source and a base is shown to be crucial for reactivity.
已经开发出一种苄醇和胺的温和分子内氟环化反应。该策略使用市售的Selectfluor引发亲电环化反应，以提供含有1,3-二取代基的氟化杂环。该试剂作为氟源和碱的双重作用对反应活性至关重要。
