Montealegre Giovanni, Uribe Rosa, Martínez-Ceballos María Alejandra, Rojas-Villarraga Adriana
Fundación Universitaria de Ciencias de la Salud (FUCS), Hospital San José, Bogotá, Colombia.
Fundación Universitaria de Ciencias de la Salud (FUCS), Cra 19 No. 8A - 32, Bogotá, Colombia.
Toxicol Rep. 2021 Jan 27;8:303-314. doi: 10.1016/j.toxrep.2021.01.011. eCollection 2021.
The number of plastic surgery procedures have been rising in the last few years. The morbi-mortality due to illegal use of biopolymers is a public health problem. One of the clinical consequences, foreign body modelling reaction, may be a precursor of ASIA (Autoimmune/Inflammatory disease induced by adjuvants) syndrome.The objective of this article is to present a case-series study of patients who developed ASIA syndrome following gluteal injection with biopolymers and emphasize the importance of toxic exposure in triggering autoimmune responses. A surgical technique used on some of the patients in the study is described.
A group of thirteen patients, diagnosed with foreign body modelling reaction, who developed ASIA syndrome confirmed by approved criteria was followed between May 2016 and May 2018. The "Butterfly Wings Technique," a new surgical procedure for patients who have medium to severe compromise, was used on five of them.A narrative literature review was done to look for subjects with ASIA syndrome and gluteal biopolymer infiltration.
All the patients in the present case-series with foreign body modelling reaction developed ASIA syndrome. Some of them had a background of familial autoimmunity. Five of the patients were surgically treated and saw a clinical improvement after the extraction of the biopolymer with the proposed technique.The narrative literature review identified 7 articles related to the disease through the database search.
We suggest that foreign body modelling reaction should be considered a precursor to ASIA syndrome. New research projects will be needed in the future to evaluate the factors that determine when ASIA syndrome is triggered in a patient with this reaction.
在过去几年中，整形手术的数量一直在增加。非法使用生物聚合物导致的病残死亡率是一个公共卫生问题。临床后果之一，异物塑形反应，可能是亚洲综合征（佐剂诱导的自身免疫/炎症性疾病）的先兆。本文的目的是介绍一组在臀部注射生物聚合物后出现亚洲综合征的患者的病例系列研究，并强调有毒暴露在引发自身免疫反应中的重要性。描述了该研究中一些患者所采用的手术技术。
2016年5月至2018年5月，对一组13名被诊断为异物塑形反应且经批准标准确诊为亚洲综合征的患者进行了随访。其中5名中度至重度受损患者采用了一种新的手术方法“蝴蝶翼技术”。进行了叙述性文献综述，以寻找患有亚洲综合征和臀部生物聚合物浸润的受试者。
本病例系列中所有有异物塑形反应的患者均出现了亚洲综合征。其中一些患者有家族自身免疫病史。5名患者接受了手术治疗，采用所提出的技术取出生物聚合物后临床症状有所改善。通过数据库搜索，叙述性文献综述确定了7篇与该疾病相关的文章。
我们建议异物塑形反应应被视为亚洲综合征的先兆。未来将需要新的研究项目来评估在有这种反应的患者中引发亚洲综合征的决定因素。
