de Tommaso Marina, Delussi Marianna, Vecchio Eleonora, Sciruicchio Vittorio, Invitto Sara, Livrea Paolo
Neuroscience and Sensory System Department, Neurophysiopathology of Pain Unit, Basical Medical Sciences, Bari University, Policlinico General Hospital, Giovanni XXIII Building, Via Amendola 207 A, 70124 Bari, Italy.
J Headache Pain. 2014 Sep 26;15(1):64. doi: 10.1186/1129-2377-15-64.
Association between sleep disorders and headache is largely known. The aim of the present study was to evaluate sleep quality and quantity in a large cohort of primary headache patients, in order to correlate these scores with symptoms of central sensitization as allodynia, pericranial tenderness and comorbidity with diffuse muscle-skeletal pain.
One thousand six hundreds and seventy primary headache out patients were submitted to the Medical Outcomes Study (MOS) within a clinical assessment, consisting of evaluation of frequency of headache, pericranial tenderness, allodynia and coexistence of fibromyalgia syndrome (FM).
Ten groups of primary headache patients were individuated, including patients with episodic and chronic migraine and tension type headache, mixed forms, cluster headache and other trigeminal autonomic cephalalgias. Duration but not sleep disturbances score was correlated with symptoms of central sensitization as allodynia and pericranial tenderness in primary headache patients. The association among allodynia, pericranial tenderness and short sleep characterized chronic migraine more than any other primary headache form. Patients presenting with FM comorbidity suffered from sleep disturbances in addition to reduction of sleep duration.
Self reported duration of sleep seems a useful index to be correlated with allodynia, pericranial tenderness and chronic headache as a therapeutic target to be assessed in forthcoming studies aiming to prevent central sensitization symptoms development.
睡眠障碍与头痛之间的关联已广为人知。本研究的目的是评估一大群原发性头痛患者的睡眠质量和数量，以便将这些评分与中枢敏化症状（如痛觉过敏、颅周压痛）以及与弥漫性肌肉骨骼疼痛的共病情况相关联。
1670名原发性头痛门诊患者在临床评估中接受了医学结局研究（MOS），该评估包括对头痛频率、颅周压痛、痛觉过敏以及纤维肌痛综合征（FM）共存情况的评估。
区分出十组原发性头痛患者，包括发作性和慢性偏头痛、紧张型头痛患者，混合型、丛集性头痛以及其他三叉自主神经性头痛患者。在原发性头痛患者中，睡眠时间而非睡眠障碍评分与中枢敏化症状（如痛觉过敏和颅周压痛）相关。痛觉过敏、颅周压痛和短睡眠之间的关联在慢性偏头痛中比在任何其他原发性头痛形式中更为明显。患有FM共病的患者除睡眠时间减少外还存在睡眠障碍。
自我报告的睡眠时间似乎是一个有用的指标，可与痛觉过敏、颅周压痛和慢性头痛相关联，作为即将开展的旨在预防中枢敏化症状发展的研究中有待评估的治疗靶点。
