Papadopoulou Erofili, Tosios Konstantinos I, Nikitakis Nikolaos, Papadogeorgakis Nikolaos, Sklavounou-Andrikopoulou Alexandra
Department of Oral Pathology and Surgery, Dental School, University of Athens, Athens, Greece.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jun;109(6):e67-71. doi: 10.1016/j.tripleo.2010.01.019.
Adenoid squamous cell carcinoma differs from common squamous cell carcinoma in histologic features and its aggressive nature. Microscopically, the tumor shows cystic degeneration of the neoplastic epithelium, producing a prominent alveolar pattern and pseudoglandular structures with acantholytic cells. It occurs most commonly on the lips, rarely intraorally, and it is associated with a poor prognosis. This case concerns a 72-year-old woman who presented with the chief complaint of burning tongue and soreness of the lips. Clinical examination revealed an ulcerated and elevated mass on the edentulous left maxillary ridge, beneath the base of a partial denture. An incisional biopsy rendered the diagnosis of adenoid squamous cell carcinoma. The patient was referred to a specialized maxillofacial surgery center for diagnostic work-up and treatment. She underwent partial maxillectomy and radiotherapy, and 17 months after treatment, she died of uncontrollable recurrence.
腺样鳞状细胞癌在组织学特征及其侵袭性方面与常见的鳞状细胞癌不同。在显微镜下，肿瘤显示肿瘤上皮的囊性退变，形成显著的肺泡样结构和带有棘层松解细胞的假腺管结构。它最常发生于唇部，很少发生于口腔内，并且预后较差。本病例为一名72岁女性，主要症状为舌部烧灼感和唇部疼痛。临床检查发现，在无牙的左上颌牙槽嵴上、局部义齿基托下方有一个溃疡且隆起的肿物。切开活检确诊为腺样鳞状细胞癌。该患者被转至一家专业的颌面外科中心进行诊断检查和治疗。她接受了部分上颌骨切除术和放射治疗，治疗17个月后，因无法控制的复发而死亡。
