Michael Smith Laboratories, 301 - 2185 East Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.
Michael Smith Laboratories, 301 - 2185 East Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z4; Department of Microbiology and Immunology, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.
J Infect. 2014 Nov;69 Suppl 1:S53-5. doi: 10.1016/j.jinf.2014.07.015. Epub 2014 Sep 26.
There is increasing evidence that environmental changes are involved in the sharp increase in asthma incidence, as well as with other immune-mediated diseases. This increase matches the introduction of modern life advances such as antibiotics and caesarean sections. Several epidemiological studies provide convincing evidence that a lack of exposure to microbes early in life is associated with later development of allergic asthma. In addition, animal studies have shown that early life modulation of the intestinal microbiota with antibiotics has profound effects in the immune cellular mechanisms that lead to asthma. By describing some of the most relevant human and animal studies in this field, we explore the concept that significant perturbations of the intestinal and perhaps the lung microbiota are a cause of allergic asthma.
越来越多的证据表明，环境变化与哮喘发病率的急剧上升以及其他免疫介导的疾病有关。这种增加与抗生素和剖腹产等现代生活进步的引入相吻合。几项流行病学研究提供了令人信服的证据，表明生命早期缺乏接触微生物与以后发生过敏性哮喘有关。此外，动物研究表明，早期用抗生素调节肠道微生物群会对导致哮喘的免疫细胞机制产生深远影响。通过描述该领域的一些最相关的人类和动物研究，我们探讨了这样一种概念，即肠道微生物群的显著改变，也许还有肺部微生物群的改变，是导致过敏性哮喘的一个原因。
