Norwegian University of Science and Technology, NTNU, Trondheim bResearch fellow, Norwegian University of Life Sciences, UMB, Ås cNorwegian University of Life Sciences, UMB, Ås, Norway. ola
Curr Opin Allergy Clin Immunol. 2013 Jun;13(3):257-62. doi: 10.1097/ACI.0b013e328360968b.
Numerous studies have attempted to describe specific microbiota deviations that may precede atopic sensitization and atopic disease in childhood. This has given rise to a hypothesis suggesting that a reduced intestinal microbial diversity in infancy increases the risk of allergic manifestations. This review intends to sum up the main findings and discuss relevant exposures that regulate intestinal microbial diversity.
Taken together the three studies in this review lend support to the diversity hypothesis, but reported differences related to atopic sensitization and clinical expression are discussed. A summary on analytic methods and functional aspect of the microbiota in allergic disease is presented to ameliorate a presentation of recent articles on environmental and host-factors regulating microbiota composition and diversity.
The current evidence indicates that intestinal microbiota diversity can be associated with allergic diseases, but the exact mechanisms and interactions contributing to this effect are far from understood and need further investigation.
许多研究试图描述可能先于儿童特应性致敏和特应性疾病的特定微生物群落偏差。这就产生了一种假设，即婴儿期肠道微生物多样性的减少会增加过敏表现的风险。本综述旨在总结主要发现，并讨论调节肠道微生物多样性的相关暴露因素。
这篇综述中的三项研究都支持多样性假说，但报告的与特应性致敏和临床表型相关的差异有待讨论。本文对过敏性疾病中微生物组的分析方法和功能方面进行了总结，以更好地介绍有关调节微生物组组成和多样性的环境和宿主因素的最新文章。
目前的证据表明，肠道微生物多样性可能与过敏性疾病有关，但确切的机制和相互作用尚不清楚，需要进一步研究。
