一种来自独行菜种子的新异黄酮及其对扑热息痛诱导的雄性大鼠肝毒性的保护作用。
A new isoflavonoid from seeds of Lepidium sativum L. and its protective effect on hepatotoxicity induced by paracetamol in male rats.
作者信息
Sakran Mohamed, Selim Yasser, Zidan Nahla
机构信息
Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt.
Faculty of Specific Education, Zagazig University, Zagazig 44519, Egypt.
出版信息
Molecules. 2014 Sep 26;19(10):15440-51. doi: 10.3390/molecules191015440.
A new isoflavonoid, 5,6-dimethoxy-2',3'-methylenedioxy-7-C-β-d-gluco-pyranosyl isoflavone was isolated from the seeds of Lepidium sativum L. along with two known isoflavonoids, 7-hydroxy-4',5,6-trimethoxyisoflavone and 7-hydroxy-5,6-dimethoxy-2',3'-methylenedioxyisoflavone. The structures of all compounds were elucidated with NMR spectrometry. Compounds 1, 2 and the new isoflavonoid 3 were evaluated for their ability to reduce the hepatotoxicity induced by paracetamol in male rats by reducing the damage and toxicity effects on liver cells with a significant improvement of total antioxidant capacity, normalizing the levels of liver enzymes GSH, SOD, GPX, CAT and GST compared to control group.
从独行菜种子中分离出一种新的异黄酮5,6-二甲氧基-2',3'-亚甲二氧基-7-C-β-D-吡喃葡萄糖基异黄酮，同时还分离出两种已知异黄酮，7-羟基-4',5,6-三甲氧基异黄酮和7-羟基-5,6-二甲氧基-2',3'-亚甲二氧基异黄酮。所有化合物的结构均通过核磁共振光谱法阐明。通过降低对肝细胞的损伤和毒性作用，显著提高总抗氧化能力，使肝酶谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）、过氧化氢酶（CAT）和谷胱甘肽S-转移酶（GST）水平恢复正常，对化合物1、2和新异黄酮3减轻对乙酰氨基酚诱导的雄性大鼠肝毒性的能力进行了评估。
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