Korhonen Päivi E, Kautiainen Hannu, Mäntyselkä Pekka
Satakunta Hospital District, Pori; Central Satakunta Health Federation of Municipalities, Harjavalta; Institute of Clinical Medicine, Family Medicine, University of Turku, Turku, Finland.
Unit of Primary Health Care, Helsinki University Central Hospital; Department of General Practice, University of Helsinki, Helsinki, Finland.
Br J Gen Pract. 2014 Oct;64(627):e611-5. doi: 10.3399/bjgp14X681769.
Self-rated health is an independent predictor of mortality. However, general health checks in populations unselected for disease or risk factors have not been shown to reduce mortality or morbidity.
To describe new comorbidities and cardiovascular risk factors in apparently healthy people and to relate this to their self-rated health.
A targeted screening programme identified 462 middle-aged people with cardiovascular risk factors without previously diagnosed chronic disease in a Finnish community in 2005-2006.
Home blood pressure monitoring, oral glucose tolerance test, estimated glomerular filtration rate, and ankle brachial index were used to detect previously undiagnosed conditions. The Short-Form Health Survey and Beck's Depression Inventory were completed by participants before the diagnostic tests were performed.
The prevalence of previously undiagnosed disease was: hypertension 113/462 (24% [95% confidence interval {CI} = 21% to 29%]), diabetes 19/462 (4% [95% CI = 2% to 6%]), renal insufficiency 23/462 (5% [95% CI = 3% to 7%]), and peripheral arterial disease 17/462 (4% [95% CI = 2% to 5%]). Of the 139 participants who regarded their health as 'fair-poor', 60 (43%) had a previously undetected condition affecting their vasculature.
Out of the screen-detected apparently healthy cardiovascular risk subjects, one in three had undiagnosed hypertension, diabetes, peripheral arterial disease, or renal insufficiency. Those individuals experiencing ill health tended to be at high risk of cardiovascular problems.
自我评估健康状况是死亡率的独立预测指标。然而,在未因疾病或风险因素而被筛选的人群中进行的常规健康检查,尚未显示出能降低死亡率或发病率。
描述表面健康人群中新发的合并症和心血管危险因素,并将其与他们自我评估的健康状况相关联。
2005 - 2006年在芬兰一个社区开展的一项针对性筛查项目,识别出462名有心血管危险因素但此前未被诊断出患有慢性病的中年人。
采用家庭血压监测、口服葡萄糖耐量试验、估算肾小球滤过率和踝臂指数来检测此前未被诊断出的疾病状况。参与者在进行诊断测试前完成简短健康调查问卷和贝克抑郁量表。
此前未被诊断出的疾病患病率为:高血压113/462(24%[95%置信区间{CI}=21%至29%]),糖尿病19/462(4%[95%CI = 2%至6%]),肾功能不全23/462(5%[95%CI = 3%至7%]),外周动脉疾病17/462(4%[95%CI = 2%至5%])。在139名认为自己健康状况为“中等 - 差”的参与者中,60名(43%)存在此前未被检测出的影响其血管系统的疾病。
在筛查发现的表面健康的心血管风险受试者中,三分之一患有未被诊断出的高血压、糖尿病、外周动脉疾病或肾功能不全。那些健康状况不佳的个体往往有较高的心血管问题风险。