Gern J E
Pediatrics and Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Clin Exp Allergy. 2015 Jan;45(1):32-42. doi: 10.1111/cea.12428.
Rhinovirus (RV) infections are closely linked to exacerbations of asthma, and yet most RV infections of patients with asthma cause only upper respiratory symptoms. These findings suggest that RV and other viral infections contribute to the causation of acute exacerbations of asthma, but that additional cofactors are generally required. In fact, factors related to the host, virus, and environment have been identified that affect the severity of RV infections, and propensity to develop lower respiratory tract symptoms. This review will discuss these factors and how their effects may act alone or in combination to increase the probability of RV-induced exacerbations of asthma.
鼻病毒（RV）感染与哮喘加重密切相关，但大多数哮喘患者的RV感染仅引起上呼吸道症状。这些发现表明，RV和其他病毒感染促成了哮喘急性加重的病因，但通常还需要其他辅助因素。事实上，已经确定了与宿主、病毒和环境相关的因素，这些因素会影响RV感染的严重程度以及出现下呼吸道症状的倾向。本综述将讨论这些因素，以及它们的影响如何单独或共同作用，以增加RV诱发哮喘加重的可能性。
