Bakken Inger Johanne, Tveito Kari, Gunnes Nina, Ghaderi Sara, Stoltenberg Camilla, Trogstad Lill, Håberg Siri Eldevik, Magnus Per
Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway.
The Norwegian Medical Association, Oslo, Norway.
BMC Med. 2014 Oct 1;12:167. doi: 10.1186/s12916-014-0167-5.
The aim of the current study was to estimate sex- and age-specific incidence rates of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) using population-based registry data. CFS/ME is a debilitating condition with large impact on patients and their families. The etiology is unknown, and the distribution of the disease in the general population has not been well described.
Cases of CFS/ME were identified in the Norwegian Patient Register (NPR) for the years 2008 to 2012. The NPR is nationwide and contains diagnoses assigned by specialist health care services (hospitals and outpatient clinics). We estimated sex- and age-specific incidence rates by dividing the number of new cases of CFS/ME in each category by the number of person years at risk. Incidence rate ratios were estimated by Poisson regression with sex, age categories, and year of diagnosis as covariates.
A total of 5,809 patients were registered with CFS/ME during 2008 to 2012. The overall incidence rate was 25.8 per 100,000 person years (95% confidence interval (CI): 25.2 to 26.5). The female to male incidence rate ratio of CFS/ME was 3.2 (95% CI: 3.0 to 3.4). The incidence rate varied strongly with age for both sexes, with a first peak in the age group 10 to 19 years and a second peak in the age group 30 to 39 years.
Early etiological clues can sometimes be gained from examination of disease patterns. The strong female preponderance and the two age peaks suggest that sex- and age-specific factors may modulate the risk of CFS/ME.
本研究旨在利用基于人群的登记数据估计慢性疲劳综合征/肌痛性脑脊髓炎（CFS/ME）的性别和年龄特异性发病率。CFS/ME是一种使人衰弱的疾病，对患者及其家庭有很大影响。其病因不明，该疾病在普通人群中的分布情况尚未得到充分描述。
在挪威患者登记处（NPR）中识别出2008年至2012年期间的CFS/ME病例。NPR覆盖全国，包含专科医疗服务机构（医院和门诊诊所）给出的诊断。我们通过将每个类别中CFS/ME新病例数除以处于风险中的人年数来估计性别和年龄特异性发病率。发病率比通过以性别、年龄类别和诊断年份作为协变量的泊松回归进行估计。
2008年至2012年期间，共有5809名患者登记患有CFS/ME。总体发病率为每10万人年25.8例（95%置信区间（CI）：25.2至26.5）。CFS/ME的女性与男性发病率比为3.2（95%CI：3.0至3.4）。两性的发病率均随年龄有很大变化，在10至19岁年龄组出现第一个高峰，在30至39岁年龄组出现第二个高峰。
有时通过检查疾病模式可以获得早期病因线索。明显的女性优势和两个年龄高峰表明性别和年龄特异性因素可能会调节CFS/ME的风险。
