O'Donnell M J, Lawson N, Barnett A H
Department of Medicine, University of Birmingham, UK.
Diabet Med. 1989 Jul;6(5):422-5. doi: 10.1111/j.1464-5491.1989.tb01197.x.
There have been conflicting reports of the activity of the renin-angiotensin-aldosterone system in diabetes. We studied the activity of the unstimulated renin-angiotensin-aldosterone system in 73 consecutive Type 1 diabetic patients with varying degrees of albuminuria. Patients with elevated albumin excretion rates had elevated median plasma renin activity (macroalbuminuric 2.2, range 0.5-8.2, p less than 0.05; microalbuminuric 2.3, 0.7-7.1, p less than 0.001; vs normoalbuminuric 1.0, 0.2-4.5 nmol l-1 h-1) and higher systolic blood pressure (macroalbuminuric 141 +/- 27 vs normoalbuminuric 116 +/- 13 mmHg, mean +/- SD, p less than 0.01) compared with those with normal albumin excretion rates. Aldosterone secretion and function were normal in all patients studied.
关于糖尿病患者肾素-血管紧张素-醛固酮系统的活性，一直存在相互矛盾的报道。我们研究了73例连续的1型糖尿病患者，这些患者蛋白尿程度各异，观察了未受刺激的肾素-血管紧张素-醛固酮系统的活性。与白蛋白排泄率正常的患者相比，白蛋白排泄率升高的患者血浆肾素活性中位数升高（大量白蛋白尿患者为2.2，范围0.5 - 8.2，p < 0.05；微量白蛋白尿患者为2.3，0.7 - 7.1，p < 0.001；而正常白蛋白尿患者为1.0，0.2 - 4.5 nmol l-1 h-1），收缩压也更高（大量白蛋白尿患者为141 ± 27，正常白蛋白尿患者为116 ± 13 mmHg，均值 ± 标准差，p < 0.01）。在所有研究的患者中，醛固酮分泌和功能均正常。
