铜介导的未活化末端烯烃的氧化三氟甲硫基化反应。
Copper-mediated oxidative trifluoromethylthiolation of unactivated terminal alkenes.
作者信息
Zhang Ke, Liu Jian-Bo, Qing Feng-Ling
机构信息
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.
出版信息
Chem Commun (Camb). 2014 Nov 25;50(91):14157-60. doi: 10.1039/c4cc07062c.
PMID:25277082
Abstract
A general method to form a C(SP(3))-SCF3 bond via copper-mediated oxidative trifluoromethylthiolation of unactivated alkenes with stable nucleophilic AgSCF3 was developed. This protocol provides a direct and efficient access to a series of trifluoromethylthiolated allylic compounds with broad functional group tolerance.
摘要
开发了一种通过铜介导的未活化烯烃与稳定亲核试剂AgSCF3的氧化三氟甲基硫醇化反应形成C(SP(3))-SCF3键的通用方法。该方案提供了一种直接有效的方法来获得一系列具有广泛官能团耐受性的三氟甲基硫醇化烯丙基化合物。
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