Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, 200032, Shanghai (China).
Angew Chem Int Ed Engl. 2015 Mar 23;54(13):4070-4. doi: 10.1002/anie.201411953. Epub 2015 Feb 23.
A practical and efficient method for the direct trifluoromethylthiolation of unactivated C(sp(3) )H bonds by AgSCF3 /K2 S2 O8 under mild conditions is described. The reaction has a good functional-group tolerance and good selectivity. Initial mechanistic investigations indicate that the reaction may involve a radical process in which K2 S2 O8 plays key roles in both the activation of the C(sp(3) )H bond and the oxidation of AgSCF3 .
AgSCF3 /K2 S2 O8 温和条件下直接实现未活化 C(sp(3) )H 键三氟甲硫基化：一种实用、高效的方法。该反应具有很好的官能团容忍性和选择性。初步的机理研究表明，该反应可能涉及自由基过程，其中 K2 S2 O8 在活化 C(sp(3) )H 键和氧化 AgSCF3 中都起着关键作用。
