使用三氟甲烷硫代银和过硫酸钾直接对未活化的 C(sp(3))-H 进行三氟甲基化。
Direct trifluoromethylthiolation of unactivated C(sp(3))-H using silver(I) trifluoromethanethiolate and potassium persulfate.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, 200032, Shanghai (China).
出版信息
Angew Chem Int Ed Engl. 2015 Mar 23;54(13):4070-4. doi: 10.1002/anie.201411953. Epub 2015 Feb 23.
A practical and efficient method for the direct trifluoromethylthiolation of unactivated C(sp(3) )H bonds by AgSCF3 /K2 S2 O8 under mild conditions is described. The reaction has a good functional-group tolerance and good selectivity. Initial mechanistic investigations indicate that the reaction may involve a radical process in which K2 S2 O8 plays key roles in both the activation of the C(sp(3) )H bond and the oxidation of AgSCF3 .
AgSCF3 /K2 S2 O8 温和条件下直接实现未活化 C(sp(3) )H 键三氟甲硫基化：一种实用、高效的方法。该反应具有很好的官能团容忍性和选择性。初步的机理研究表明，该反应可能涉及自由基过程，其中 K2 S2 O8 在活化 C(sp(3) )H 键和氧化 AgSCF3 中都起着关键作用。
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