Xiao Jing-Ru, Do Chi-Wai, To Chi-Ho
1 Laboratory of Experimental Optometry, School of Optometry, The Hong Kong Polytechnic University , Hung Hom, Hong Kong , Hong Kong.
J Ocul Pharmacol Ther. 2014 Oct;30(8):605-14. doi: 10.1089/jop.2014.0074.
Ocular diseases such as cataract, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy are the leading causes of blindness. The elderly population is at particular risk of developing one or more of these age-related ocular diseases. By virtue of multiple bioactivities, effort has been made to develop dietary flavonoids as complimentary therapies for ocular disorders. Dietary intake of flavonoids has been reported to reduce the risk of cataract and AMD. This review focuses on the main flavones baicalein, baicalin, and wogonin isolated from the Chinese medicinal herb, Scutellariae radix (SR), which has been widely used in Asian countries for the treatment of many diseases. Interest in SR has grown recently following new findings that suggest multiple routes of therapeutic action. This review will summarize the diverse pharmacological properties, therapeutic roles, and mechanisms of these flavones of SR in cellular and animal models of ocular diseases.
白内障、青光眼、年龄相关性黄斑变性（AMD）和糖尿病性视网膜病变等眼部疾病是失明的主要原因。老年人群尤其容易患上一种或多种此类与年龄相关的眼部疾病。由于具有多种生物活性，人们致力于开发膳食黄酮类化合物作为眼部疾病的辅助治疗方法。据报道，膳食中摄入黄酮类化合物可降低患白内障和AMD的风险。本综述重点关注从中药黄芩（SR）中分离出的主要黄酮类化合物黄芩素、黄芩苷和汉黄芩素，黄芩在亚洲国家已被广泛用于治疗多种疾病。最近有新发现表明其具有多种治疗作用途径，这使得人们对黄芩的兴趣有所增加。本综述将总结这些黄芩黄酮类化合物在眼部疾病细胞和动物模型中的多种药理特性、治疗作用及机制。
