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热致相分离法制备可生物降解组织工程支架的最新进展。

Recent Progress on Biodegradable Tissue Engineering Scaffolds Prepared by Thermally-Induced Phase Separation (TIPS).

机构信息

Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Escola d'Enginyeria de Barcelona Est-EEBE, 08019 Barcelona, Spain.

Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, c/Baldiri Reixac 10-12, 08028 Barcelona, Spain.

出版信息

Int J Mol Sci. 2021 Mar 28;22(7):3504. doi: 10.3390/ijms22073504.

DOI:10.3390/ijms22073504
PMID:33800709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8036748/
Abstract

Porous biodegradable scaffolds provide a physical substrate for cells allowing them to attach, proliferate and guide the formation of new tissues. A variety of techniques have been developed to fabricate tissue engineering (TE) scaffolds, among them the most relevant is the thermally-induced phase separation (TIPS). This technique has been widely used in recent years to fabricate three-dimensional (3D) TE scaffolds. Low production cost, simple experimental procedure and easy processability together with the capability to produce highly porous scaffolds with controllable architecture justify the popularity of TIPS. This paper provides a general overview of the TIPS methodology applied for the preparation of 3D porous TE scaffolds. The recent advances in the fabrication of porous scaffolds through this technique, in terms of technology and material selection, have been reviewed. In addition, how properties can be effectively modified to serve as ideal substrates for specific target cells has been specifically addressed. Additionally, examples are offered with respect to changes of TIPS procedure parameters, the combination of TIPS with other techniques and innovations in polymer or filler selection.

摘要

多孔可生物降解支架为细胞提供物理基质，使它们能够附着、增殖并引导新组织的形成。已经开发出多种制造组织工程（TE）支架的技术，其中最相关的是热致相分离（TIPS）。近年来，该技术已被广泛用于制造三维（3D）TE 支架。低制造成本、简单的实验程序和易于加工性以及能够生产具有可控结构的高多孔支架，这使得 TIPS 广受欢迎。本文提供了 TIPS 方法在制备 3D 多孔 TE 支架方面的应用概述。综述了通过该技术在多孔支架制造方面的最新进展，包括技术和材料选择方面。此外，还专门讨论了如何有效地改变性能以作为特定靶细胞的理想基质。此外，还提供了有关 TIPS 程序参数变化、TIPS 与其他技术的结合以及聚合物或填充剂选择方面的创新的示例。

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