Surdam Jonathan W, Licini David J, Baynes Nathan T, Arce Britney R
Department of Orthopedics, Indiana University Health Bloomington, Bloomington, Indiana.
J Arthroplasty. 2015 Feb;30(2):325-9. doi: 10.1016/j.arth.2014.09.004. Epub 2014 Sep 16.
Efforts continue to improve pain after total knee arthroplasty (TKA) in order to allow for accelerated rehabilitation. The purpose of this study was to evaluate pain control after TKA. A randomized prospective study of 80 consecutive patients was performed comparing Exparel versus femoral nerve block (FNB). Inpatient pain control was the primary outcome. Secondary outcome measures included ROM (extension and flexion), nausea and vomiting, narcotic consumption, ambulation distance, and length of stay (LOS). There were no statistically significant differences between the groups with regard to pain, nausea and vomiting, and narcotic consumption. The FNB group had greater flexion but the Exparel group had improved early ambulation and decreased LOS. Exparel provided similar pain relief to a FNB after TKA without compromising early rehabilitation.
为了实现加速康复，人们一直在努力改善全膝关节置换术（TKA）后的疼痛状况。本研究的目的是评估TKA后的疼痛控制情况。对80例连续患者进行了一项随机前瞻性研究，比较了Exparel与股神经阻滞（FNB）的效果。住院期间的疼痛控制是主要结局指标。次要结局指标包括关节活动度（伸展和屈曲）、恶心和呕吐、麻醉药物用量、行走距离以及住院时间（LOS）。两组在疼痛、恶心和呕吐以及麻醉药物用量方面无统计学显著差异。FNB组的屈曲度更大，但Exparel组的早期行走能力有所改善且住院时间缩短。TKA后，Exparel提供了与FNB相似的疼痛缓解效果，且不影响早期康复。
