Cunliffe W J, Holland K T
Department of Dermatology, Leeds General Infirmary, Yorkshire, England.
Acta Derm Venereol Suppl (Stockh). 1989;143:31-4. doi: 10.2340/000155551433134.
In a series of investigations using 20% azelaic acid cream as a therapy for acne, it was found that the treatment, compared with its placebo, significantly reduced inflamed lesions after 1 month and non-inflamed lesions after 2 months. No changes in sebum excretion rate occurred, but a significant reduction, 15.9 to 10.5%, of free fatty acids of skin surface lipid was detected after 1 month. The follicular Micrococaceae density was significantly reduced after 1 month, and after 2 months there was a significant reduction in follicular Propionibacterium spp density. The final reductions were 2,500 and 44 fold, respectively.
在一系列使用20%壬二酸乳膏治疗痤疮的研究中，发现与安慰剂相比，该治疗在1个月后显著减少了炎性皮损，在2个月后显著减少了非炎性皮损。皮脂排泄率没有变化，但在1个月后检测到皮肤表面脂质的游离脂肪酸显著降低，从15.9%降至10.5%。1个月后毛囊微球菌密度显著降低，2个月后毛囊丙酸杆菌属密度显著降低。最终的降低倍数分别为2500倍和44倍。
