Cavicchini S, Caputo R
First Clinic of Dermatology, University of Milan, Italy.
Acta Derm Venereol Suppl (Stockh). 1989;143:40-4.
Preliminary clinical studies (2) proved the effectiveness of topical azelaic acid (AZA) in the treatment of acne vulgaris. During the period of 1982-86 we carried out two studies with 20% AZA cream in patients with acne to determine its clinical indications and therapeutic schedules. The first, open study was of 100 unselected patients of either sex, while a second group of 30 patients formed a part of a larger (309 patients) multicentre single-blind comparison of topical AZA vs. 5% benzoylperoxide (BPO) gel for the treatment of papulopustular acne. The rates of improvement obtained indicate that topical AZA can be considered an effective therapy chiefly for papulo-pustular acne, with a very good local tolerance.
初步临床研究（2）证明了外用壬二酸（AZA）治疗寻常痤疮的有效性。在1982年至1986年期间，我们对20%的AZA乳膏治疗痤疮患者进行了两项研究，以确定其临床适应证和治疗方案。第一项开放性研究纳入了100名未经挑选的男女患者，而另一组30名患者则是一项更大规模（309名患者）的多中心单盲比较研究的一部分，该研究比较了外用AZA与5%过氧化苯甲酰（BPO）凝胶治疗丘疹脓疱性痤疮的效果。所获得的改善率表明，外用AZA主要可被视为治疗丘疹脓疱性痤疮的有效疗法，且局部耐受性良好。
