人乳头瘤病毒（HPV）——结构、流行病学及发病机制

Human Papillomavirus (HPV) - structure, epidemiology and pathogenesis.

作者信息

Morshed Kamal, Polz-Gruszka Dorota, Szymański Marcin, Polz-Dacewicz Małgorzata

机构信息

Katedra i Klinika Otolaryngologii i Onkologii Laryngologicznej Uniwersytetu Medycznego w Lublinie, Poland.

Zakład Wirusologii Uniwersytetu Medycznego w Lublinie, Poland.

出版信息

Otolaryngol Pol. 2014 Sep-Oct;68(5):213-9. doi: 10.1016/j.otpol.2014.06.001. Epub 2014 Jun 27.

DOI:10.1016/j.otpol.2014.06.001

PMID:25283316

Abstract

The number of cancers is constantly increasing. An important role in the etiology of many of them is played by the viral factor, by oncogenic viruses, such as the Human Papillomavirus. The article shows current epidemiological situation and describes the structure of the virus and modes of transmission. It also explains the role of HPV infection in cancer with particular emphasis on oropharynx and head and neck cancer. Summarizing, HPV infection plays an important role in carcinogenesis of the oropharynx tumors. The presence of viral genetic material in the tumor may influence prognosis and treatment method choices.

摘要

癌症的数量在不断增加。在许多癌症的病因中，病毒因素起着重要作用，如致癌病毒，如人乳头瘤病毒。本文展示了当前的流行病学情况，并描述了该病毒的结构和传播方式。它还解释了HPV感染在癌症中的作用，特别强调了口咽癌和头颈癌。总之，HPV感染在口咽肿瘤的致癌过程中起着重要作用。肿瘤中病毒遗传物质的存在可能会影响预后和治疗方法的选择。