利用超小无源传感器进行连续无线压力监测和映射，用于健康监测和重症监护。

Continuous wireless pressure monitoring and mapping with ultra-small passive sensors for health monitoring and critical care.

机构信息

Department of Electrical Engineering, Stanford University, Stanford, California 94305, USA.

Department of Materials Science and Engineering, Stanford University, Stanford, California 94305, USA.

出版信息

Nat Commun. 2014 Oct 6;5:5028. doi: 10.1038/ncomms6028.

DOI:10.1038/ncomms6028

PMID:25284074

Abstract

Continuous monitoring of internal physiological parameters is essential for critical care patients, but currently can only be practically achieved via tethered solutions. Here we report a wireless, real-time pressure monitoring system with passive, flexible, millimetre-scale sensors, scaled down to unprecedented dimensions of 1 × 1 × 0.1 cubic millimeters. This level of dimensional scaling is enabled by novel sensor design and detection schemes, which overcome the operating frequency limits of traditional strategies and exhibit insensitivity to lossy tissue environments. We demonstrate the use of this system to capture human pulse waveforms wirelessly in real time as well as to monitor in vivo intracranial pressure continuously in proof-of-concept mice studies using sensors down to 2.5 × 2.5 × 0.1 cubic millimeters. We further introduce printable wireless sensor arrays and show their use in real-time spatial pressure mapping. Looking forward, this technology has broader applications in continuous wireless monitoring of multiple physiological parameters for biomedical research and patient care.

摘要

连续监测内部生理参数对于危重病患者至关重要，但目前只能通过有绳解决方案实际实现。在这里，我们报告了一种具有无线、实时压力监测系统的被动、灵活的毫米级传感器，其尺寸缩小到前所未有的 1×1×0.1 立方毫米。这种尺寸缩小是通过新颖的传感器设计和检测方案实现的，克服了传统策略的工作频率限制，并对有损耗的组织环境不敏感。我们展示了该系统的实际应用，可无线实时捕获人体脉搏波形，并在概念验证小鼠研究中使用尺寸缩小到 2.5×2.5×0.1 立方毫米的传感器连续监测颅内压。我们进一步介绍了可打印的无线传感器阵列，并展示了它们在实时空间压力映射中的应用。展望未来，该技术在生物医学研究和患者护理中对多个生理参数的连续无线监测具有更广泛的应用。