Finzi Alessandro, Strobbe Ernesto, Tassi Filippo, Fresina Michela, Cellini Mauro
Department of Specialized, Diagnostic and Experimental Medicine, Ophthalmology Service, University of Bologna, Bologna, Italy.
Clin Ophthalmol. 2014 Sep 22;8:1929-36. doi: 10.2147/OPTH.S67193. eCollection 2014.
To assess the sensitivity and specificity of hemifield pattern electroretinogram (HF-PERG) for detecting early retinal ganglion cell (RGC) damage in ocular hypertensive (OH) patients.
Fifty-two OH patients (mean age 56±9.6 years) with an intraocular pressure (IOP) .21 mmHg were assessed. All subjects underwent HF-PERG, optical coherence tomography (OCT), and frequency doubling technology (FDT) visual field.
OH patients showed a significant increase of peak-time of the N95 (P=0.027) compared to controls. The amplitude of the N95 of the lower and upper HF-PERG showed significant differences (P=0.037 and P=0.023, respectively) between the two groups. A significant intraocular (P=0.006) and interocular (P=0.018) asymmetry of N95 amplitude was found. Receiver operating characteristic (ROC) curve analysis revealed a sensitivity of 93% for the N95 of the lower HF-PERG, whereas full-field pattern electroretinogram (PERG) N95 peak-time had a sensitivity of 88%. In OH patients, we found a thinning of OCT - retinal nerve fiber layer (RNFL), especially in the superior and inferior quadrant, although not statistically significant, and a significantly higher FDT pattern standard deviation (FDT-PSD; P=0.001). In the OCT-RNFL inferior quadrant, a sensitivity of 82% was recorded. Finally, the sensitivity of the FDT-PSD was 92%.
Our study shows that HF-PERG is a very sensitive test for detecting early damage of the RGC.
评估半视野图形视网膜电图（HF-PERG）检测高眼压（OH）患者早期视网膜神经节细胞（RGC）损伤的敏感性和特异性。
对52例眼压（IOP）>21 mmHg的OH患者（平均年龄56±9.6岁）进行评估。所有受试者均接受HF-PERG、光学相干断层扫描（OCT）和频率加倍技术（FDT）视野检查。
与对照组相比，OH患者N95的峰时显著增加（P = 0.027）。两组之间，下、上HF-PERG的N95振幅存在显著差异（分别为P = 0.037和P = 0.023）。发现N95振幅存在显著的眼内（P = 0.006）和眼间（P = 0.018）不对称。受试者操作特征（ROC）曲线分析显示，下HF-PERG的N95敏感性为93%，而全视野图形视网膜电图（PERG）N95峰时的敏感性为88%。在OH患者中，我们发现OCT - 视网膜神经纤维层（RNFL）变薄，尤其是在上下象限，尽管无统计学意义，且FDT图形标准差（FDT-PSD）显著更高（P = 0.001）。在OCT-RNFL下象限，记录到的敏感性为82%。最后，FDT-PSD的敏感性为92%。
我们的研究表明，HF-PERG是检测RGC早期损伤的非常敏感的检查。
