高眼压症患者的半视野图形视网膜电图：与频率加倍技术及光学相干断层扫描检测早期视神经病变的比较

Hemifield pattern electroretinogram in ocular hypertension: comparison with frequency doubling technology and optical coherence tomography to detect early optic neuropathy.

作者信息

Finzi Alessandro, Strobbe Ernesto, Tassi Filippo, Fresina Michela, Cellini Mauro

机构信息

Department of Specialized, Diagnostic and Experimental Medicine, Ophthalmology Service, University of Bologna, Bologna, Italy.

出版信息

Clin Ophthalmol. 2014 Sep 22;8:1929-36. doi: 10.2147/OPTH.S67193. eCollection 2014.

DOI:10.2147/OPTH.S67193

PMID:25284979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4181626/

Abstract

BACKGROUND

To assess the sensitivity and specificity of hemifield pattern electroretinogram (HF-PERG) for detecting early retinal ganglion cell (RGC) damage in ocular hypertensive (OH) patients.

METHODS

Fifty-two OH patients (mean age 56±9.6 years) with an intraocular pressure (IOP) .21 mmHg were assessed. All subjects underwent HF-PERG, optical coherence tomography (OCT), and frequency doubling technology (FDT) visual field.

RESULTS

OH patients showed a significant increase of peak-time of the N95 (P=0.027) compared to controls. The amplitude of the N95 of the lower and upper HF-PERG showed significant differences (P=0.037 and P=0.023, respectively) between the two groups. A significant intraocular (P=0.006) and interocular (P=0.018) asymmetry of N95 amplitude was found. Receiver operating characteristic (ROC) curve analysis revealed a sensitivity of 93% for the N95 of the lower HF-PERG, whereas full-field pattern electroretinogram (PERG) N95 peak-time had a sensitivity of 88%. In OH patients, we found a thinning of OCT - retinal nerve fiber layer (RNFL), especially in the superior and inferior quadrant, although not statistically significant, and a significantly higher FDT pattern standard deviation (FDT-PSD; P=0.001). In the OCT-RNFL inferior quadrant, a sensitivity of 82% was recorded. Finally, the sensitivity of the FDT-PSD was 92%.

CONCLUSION

Our study shows that HF-PERG is a very sensitive test for detecting early damage of the RGC.

摘要

背景

评估半视野图形视网膜电图（HF-PERG）检测高眼压（OH）患者早期视网膜神经节细胞（RGC）损伤的敏感性和特异性。

方法

对52例眼压（IOP）>21 mmHg的OH患者（平均年龄56±9.6岁）进行评估。所有受试者均接受HF-PERG、光学相干断层扫描（OCT）和频率加倍技术（FDT）视野检查。

结果

与对照组相比，OH患者N95的峰时显著增加（P = 0.027）。两组之间，下、上HF-PERG的N95振幅存在显著差异（分别为P = 0.037和P = 0.023）。发现N95振幅存在显著的眼内（P = 0.006）和眼间（P = 0.018）不对称。受试者操作特征（ROC）曲线分析显示，下HF-PERG的N95敏感性为93%，而全视野图形视网膜电图（PERG）N95峰时的敏感性为88%。在OH患者中，我们发现OCT - 视网膜神经纤维层（RNFL）变薄，尤其是在上下象限，尽管无统计学意义，且FDT图形标准差（FDT-PSD）显著更高（P = 0.001）。在OCT-RNFL下象限，记录到的敏感性为82%。最后，FDT-PSD的敏感性为92%。