Muwonge Haruna, Kikomeko Sharif, Sembajjwe Larry Fred, Seguya Abdul, Namugwanya Christine
Department of Medical Physiology, School of Biomedical Sciences, Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda.
School of Medicine, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
ISRN Trop Med. 2013;2013:1-9. doi: 10.1155/2013/673798.
Malaria remains endemic in Sub-Saharan Africa. Hematological changes that occur have been suggested as potential predictors of malaria. This study was aimed at evaluating the diagnostic relevance of hematological parameters in predicting malaria.
A cross-sectional study involving 370 patients with signs and symptoms of malaria was conducted at Mulago Hospital, Kampala, from May, 2012 to February, 2013. Thin and thick blood films were prepared for each patient and stained with Giemsa to aid the detection of malaria parasites. Patients' hematological parameters were determined.
Out of the 370 patients, 61 (16.5%) had malaria. Significant differences in the hematological parameters between malaria parasitemic patients and nonparasitemic patients were only observed in mean (±SD) of the differential monocyte count (10.89 ± 6.23% versus 8.98 ± 5.02%, = 0.01) and the platelet count (172.43 (± 80.41) ×10 cells/l versus 217.82 ± (95.96) ×10 cells/l = 0.00). The mean (±SD) values of the red blood cell indices (hemoglobin count, MCV, MCH, and MCHC), the differential neutrophil and lymphocyte counts, and the mean platelet volume (MPV) did not significantly differ between the two groups.
Hematological changes are unreliable laboratory indicators of malaria in acute uncomplicated malaria.
疟疾在撒哈拉以南非洲地区仍然流行。已有人提出发生的血液学变化可能是疟疾的潜在预测指标。本研究旨在评估血液学参数在预测疟疾方面的诊断相关性。
2012年5月至2013年2月，在坎帕拉的穆拉戈医院对370例有疟疾症状和体征的患者进行了一项横断面研究。为每位患者制备薄血膜和厚血膜，并用吉姆萨染色以辅助检测疟原虫。测定患者的血液学参数。
在370例患者中，61例（16.5%）患有疟疾。仅在单核细胞分类计数的平均值（±标准差）（10.89±6.23%对8.98±5.02%，P = 0.01）和血小板计数（172.43（±80.41）×10⁹细胞/升对217.82±（95.96）×10⁹细胞/升，P = 0.00）方面，疟原虫血症患者和无疟原虫血症患者的血液学参数存在显著差异。两组之间红细胞指数（血红蛋白计数、平均红细胞体积、平均红细胞血红蛋白含量和平均红细胞血红蛋白浓度）、中性粒细胞和淋巴细胞分类计数以及平均血小板体积的平均值（±标准差）没有显著差异。
在急性非复杂性疟疾中，血液学变化是不可靠的疟疾实验室指标。
