A Ali Elrazi, M Abdalla Tajeldin, Adam Ishag
Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Faculty of Medicine, Kassala University, Kassala, Sudan.
F1000Res. 2017 Jun 12;6:865. doi: 10.12688/f1000research.11767.1. eCollection 2017.
The association between the haematological profile (including abnormal platelets) and malaria is not completely understood. There are few published data on haematological profiles of malaria patients in areas with unstable malaria transmission. The current study was conducted to investigate if the haematological parameters, including platelet indices, were reliable predictors for microscopically-diagnosed malaria infection.
A case-control study with a total of 324 participants (162 in each arm) was conducted at the out-patient clinic of New Halfa hospital during the rainy and post rainy season (August 2014 through to January 2015). The cases were patients with uncomplicated (107; 66.9%) and malaria (55, 34.0%) infections. The controls were aparasitemic individuals. The haematological parameters were investigated using an automated hemo-analyser.
There was no significant difference in the mean (±SD) age between the study groups; however, compared to the controls, patients with uncomplicated malaria had significantly lower haemoglobin, leucocyte and platelet counts, and significantly higher red cell distribution width (RDW), platelet distribution width (PDW) and mean platelet volume (MPV).
The study revealed that among the haematological indices, PDW and MPV were the main predictors for uncomplicated and P malaria infection Abbreviations: OR: odds ratio.
血液学指标（包括血小板异常）与疟疾之间的关联尚未完全明确。在疟疾传播不稳定地区，关于疟疾患者血液学指标的已发表数据较少。本研究旨在调查包括血小板指标在内的血液学参数是否为显微镜诊断的疟疾感染的可靠预测指标。
2014年8月至2015年1月的雨季和雨季过后，在新哈尔法医院门诊部进行了一项病例对照研究，共有324名参与者（每组162名）。病例为单纯性疟疾（107例；66.9%）和疟疾（55例，34.0%）感染患者。对照组为未感染疟原虫的个体。使用自动血液分析仪检测血液学参数。
研究组之间的平均（±标准差）年龄无显著差异；然而，与对照组相比，单纯性疟疾患者的血红蛋白、白细胞和血小板计数显著降低，红细胞分布宽度（RDW）、血小板分布宽度（PDW）和平均血小板体积（MPV）显著升高。
研究表明，在血液学指标中，PDW和MPV是单纯性疟疾和疟疾感染的主要预测指标。缩写：OR：比值比。
