卷曲霉素，一种新型抗菌生物碱，包含来自弯孢霉属的两个未被描述的结构单元。
Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species.
机构信息
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093, China.
出版信息
Org Lett. 2014 Oct 17;16(20):5366-9. doi: 10.1021/ol502572g. Epub 2014 Oct 6.
The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.
白姑鱼（Argyrosomus argentatus）来源的弯颈霉（Curvularia sp. IFB-Z10）产生了弯颈霉胺，这是一种具有全新骨架的生物碱，包含两个未被描述的伸展单元。与替硝唑相比，弯颈霉胺具有更高的选择性抗菌活性，并且在通过寡肽基序与丙氨酸之间的脱羧缩合形成的新伸展单元方面具有生物合成上的独特性。
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