Kohlhoff Stephan A, Huband Michael D, Hammerschlag Margaret R
Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
Infection iMed, AstraZeneca Pharmaceuticals LP, Waltham, Massachusetts, USA.
Antimicrob Agents Chemother. 2014 Dec;58(12):7595-6. doi: 10.1128/AAC.03920-14. Epub 2014 Oct 6.
The in vitro activities of AZD0914, levofloxacin, azithromycin, and doxycycline against 10 isolates each of Chlamydia trachomatis and Chlamydia pneumoniae were tested. For AZD0914, the MIC90s for C. trachomatis and C. pneumoniae were 0.25 μg/ml (range, 0.06 to 0.5 μg/ml) and 1 μg/ml (range, 0.25 to 1 μg/ml), respectively, and the minimal bactericidal concentrations at which 90% of the isolates were killed (MBC90s) were 0.5 μg/ml for C. trachomatis (range, 0.125 to 1 μg/ml) and 2 μg/ml for C. pneumoniae (range, 0.5 to 2 μg/ml).
测试了AZD0914、左氧氟沙星、阿奇霉素和多西环素对沙眼衣原体和肺炎衣原体各10株分离株的体外活性。对于AZD0914,沙眼衣原体和肺炎衣原体的MIC90分别为0.25μg/ml(范围为0.06至0.5μg/ml)和1μg/ml(范围为0.25至1μg/ml),90%分离株被杀死时的最低杀菌浓度(MBC90),沙眼衣原体为0.5μg/ml(范围为0.125至1μg/ml),肺炎衣原体为2μg/ml(范围为0.5至2μg/ml)。