阿奇霉素（CP - 62,993）对沙眼衣原体和肺炎衣原体的体外活性。
In vitro activity of azithromycin (CP-62,993) against Chlamydia trachomatis and Chlamydia pneumoniae.
作者信息
Agacfidan A, Moncada J, Schachter J
机构信息
Department of Microbiology, Istanbul Faculty of Medicine, Turkey.
出版信息
Antimicrob Agents Chemother. 1993 Sep;37(9):1746-8. doi: 10.1128/AAC.37.9.1746.
Abstract
The in vitro susceptibilities of 49 strains of Chlamydia trachomatis and 3 strains of Chlamydia pneumoniae to azithromycin and tetracycline or doxycycline were determined. The MIC of azithromycin ranged from < or = 0.06 to 1.0 micrograms/ml, the MIC of tetracycline ranged from 0.03 to 0.12 micrograms/ml, and the MIC of doxycycline ranged from 0.015 to 0.06 micrograms/ml against C. trachomatis. The MIC ranges for C. pneumoniae were 0.12 to 0.25 micrograms/ml for azithromycin and 0.06 to 0.12 micrograms/ml for tetracycline. All minimal chlamydicidal concentrations were either equal to the MIC or one or two dilutions higher. No strains resistant to these antibiotics were detected. In vitro activity shows that azithromycin is highly active against C. trachomatis and C. pneumoniae.
摘要
测定了49株沙眼衣原体和3株肺炎衣原体对阿奇霉素、四环素或多西环素的体外敏感性。针对沙眼衣原体，阿奇霉素的最低抑菌浓度（MIC）范围为≤0.06至1.0微克/毫升，四环素的MIC范围为0.03至0.12微克/毫升，多西环素的MIC范围为0.015至0.06微克/毫升。针对肺炎衣原体，阿奇霉素的MIC范围为0.12至0.25微克/毫升，四环素的MIC范围为0.06至0.12微克/毫升。所有最小杀衣原体浓度均等于MIC或比MIC高1倍或2倍稀释度。未检测到对这些抗生素耐药的菌株。体外活性表明，阿奇霉素对沙眼衣原体和肺炎衣原体具有高度活性。
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本文引用的文献
1
Relative resistance to erythromycin in Chlamydia trachomatis.沙眼衣原体对红霉素的相对耐药性。
Antimicrob Agents Chemother. 1980 Nov;18(5):696-8. doi: 10.1128/AAC.18.5.696.
2
Treatment of Chlamydia trachomatis infections: comparison of 1- and 2-g doses of erythromycin daily for seven days.沙眼衣原体感染的治疗：每日1克和2克剂量红霉素连续服用七天的比较。
Sex Transm Dis. 1987 Apr-Jun;14(2):102-6.
3
Treatment of sexually transmitted chlamydial infections.性传播衣原体感染的治疗
JAMA. 1986 Apr 4;255(13):1750-6.
4
In vitro evaluation of CP-62,993, erythromycin, clindamycin, and tetracycline against Chlamydia trachomatis.CP-62,993、红霉素、克林霉素和四环素对沙眼衣原体的体外评估
Antimicrob Agents Chemother. 1987 May;31(5):811-2. doi: 10.1128/AAC.31.5.811.
5
In vitro susceptibilities of Chlamydia pneumoniae (Chlamydia sp. strain TWAR).肺炎衣原体（衣原体属TWAR株）的体外药敏试验
Antimicrob Agents Chemother. 1989 Sep;33(9):1634-5. doi: 10.1128/AAC.33.9.1634.
6
Chlamydia pneumoniae, strain TWAR.
Chest. 1989 Mar;95(3):664-9. doi: 10.1378/chest.95.3.664.
7
The pharmacokinetics of azithromycin in human serum and tissues.阿奇霉素在人血清和组织中的药代动力学。
J Antimicrob Chemother. 1990 Jan;25 Suppl A:73-82. doi: 10.1093/jac/25.suppl_a.73.
8
Chlamydia trachomatis: in vitro susceptibility of genital and ocular isolates to some quinolones, amoxicillin and azithromycin.沙眼衣原体：生殖道和眼部分离株对某些喹诺酮类药物、阿莫西林和阿奇霉素的体外敏感性
Chemotherapy. 1990;36(6):407-15. doi: 10.1159/000238797.
9
Comparison of three-day and five-day courses of azithromycin in the treatment of atypical pneumonia.阿奇霉素三日疗程与五日疗程治疗非典型肺炎的比较。
Eur J Clin Microbiol Infect Dis. 1991 Oct;10(10):877-80. doi: 10.1007/BF01975847.
10
A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial Infections Study Group.单剂量阿奇霉素治疗衣原体尿道炎和宫颈炎的对照试验。衣原体感染阿奇霉素研究组。
N Engl J Med. 1992 Sep 24;327(13):921-5. doi: 10.1056/NEJM199209243271304.
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