Mamtani Ravinder, Lowenfels Albert B, Sheikh Javaid, Cheema Sohaila, Al-Hamaq Abdulla, Matthis Sharoud A, El-Nahas Katie G, Maisonneuve Patrick
Department of Global and Public Health, Weill Cornell Medical College in Qatar, Qatar Foundation - Education City, Doha 24144, Qatar.
New York Medical College, Valhalla, NY 10595, USA.
JRSM Open. 2014 Jul 8;5(8):2054270414536550. doi: 10.1177/2054270414536550. eCollection 2014 Aug.
To estimate the prevalence of prediabetes in adolescents living in a high-risk country and to detect risk factors associated with this disorder.
Survey questionnaire combined with physical measurements and blood sugar determination.
Doha, capital city of Qatar.
A total of 1694 male and female students aged 11-18 years without previously diagnosed diabetes enrolled in four schools.
Blood sugar measurements. Other measured variables included gender, height, weight, abdominal circumference, country of origin, family history of diabetes and frequency of exercise.
Using a random blood sugar ≥7.8 mmol/L or a fasting blood sugar ≥5.5 mmol/L as cutpoints, we identified 4.2% of students (56 boys, 15 girls) as probable prediabetics. In a multivariate model, being boys (OR 3.2, 95% CI 1.7-6.2), having a diabetic parent (OR 1.9, 95% CI 1.1-3.2) or having a waist-to-height ratio >0.5 (OR 1.8, 95% CI 1.1-3.0) were significantly associated with being a prediabetic. The parental origin of diabetes had a differential effect upon blood sugar. The mean random blood sugar in students with a maternal inheritance pattern of diabetes was 5.61 mmol/L ± 1.0, compared to 5.39 mmol/L ± 0.89 in students with a paternal inheritance pattern (p = 0.02).
In a country with a high risk of adult diabetes, we identified 4.2% of students aged 11-18 as being prediabetic. Risk factors associated with prediabetes included male gender, family history of diabetes and waist-to-height ratio >0.5.
评估生活在高危国家的青少年中糖尿病前期的患病率，并检测与此疾病相关的危险因素。
调查问卷结合体格测量和血糖测定。
卡塔尔首都多哈。
共有1694名年龄在11 - 18岁、既往未被诊断出患有糖尿病的男女学生，他们来自四所学校。
血糖测量。其他测量变量包括性别、身高、体重、腹围、原籍国、糖尿病家族史和运动频率。
以随机血糖≥7.8 mmol/L或空腹血糖≥5.5 mmol/L为切点，我们确定4.2%的学生（56名男孩，15名女孩）可能患有糖尿病前期。在多变量模型中，男性（比值比3.2，95%置信区间1.7 - 6.2）、有糖尿病父母（比值比1.9，95%置信区间1.1 - 3.2）或腰高比>0.5（比值比1.8，95%置信区间1.1 - 3.0）与糖尿病前期显著相关。糖尿病的父母遗传来源对血糖有不同影响。糖尿病母系遗传模式的学生平均随机血糖为5.61 mmol/L ± 1.0，而父系遗传模式的学生为5.39 mmol/L ± 0.89（p = 0.02）。
在一个成人糖尿病风险较高的国家，我们确定11 - 18岁的学生中有4.2%患有糖尿病前期。与糖尿病前期相关的危险因素包括男性、糖尿病家族史和腰高比>0.5。
