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人类T淋巴细胞上抗原受体的描绘。

The delineation of antigen receptors on human T lymphocytes.

作者信息

Reinherz E L, Meuer S C, Schlossman S F

机构信息

The Division of Tumor Immunology, Sidney Farber Cancer Institute and the Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Immunol Today. 1983 Jan;4(1):5-8. doi: 10.1016/0167-5699(83)90094-4.

DOI:10.1016/0167-5699(83)90094-4
PMID:25290891
Abstract

Monoclonal antibodies have identified several surface molecules involved in target cell recognition by cytotoxic human T cells. In this article it is proposed that T cells have two recognition units: a complex composed of the T3 molecule and a clonally unique glycoprotein which binds antigen associated with polymorphic MHC gene product; and the T4 or T8 molecule which binds to a constant region of an MHC gene product.

摘要

单克隆抗体已识别出几种参与细胞毒性人T细胞识别靶细胞的表面分子。本文提出，T细胞有两个识别单位：一个由T3分子和一种克隆独特的糖蛋白组成的复合物，该糖蛋白结合与多态性MHC基因产物相关的抗原；以及与MHC基因产物恒定区结合的T4或T8分子。

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1
The delineation of antigen receptors on human T lymphocytes.人类T淋巴细胞上抗原受体的描绘。
Immunol Today. 1983 Jan;4(1):5-8. doi: 10.1016/0167-5699(83)90094-4.
2
Surface molecules involved in self-recognition and T cell activation in the autologous mixed lymphocyte reaction.自体混合淋巴细胞反应中参与自我识别和T细胞活化的表面分子。
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Accessory cell-T cell interactions involved in anti-CD3-induced T4 and T8 cell proliferation: analysis with monoclonal antibodies.抗CD3诱导的T4和T8细胞增殖中辅助细胞与T细胞的相互作用：单克隆抗体分析
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Evidence for a regulatory role of the T8 (CD8) antigen in antigen-specific and anti-T3-(CD3)-induced lytic activity of allospecific cytotoxic T lymphocyte clones.T8（CD8）抗原在同种特异性细胞毒性T淋巴细胞克隆的抗原特异性及抗T3 -（CD3）诱导的裂解活性中起调节作用的证据。
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T8 and T3 surface glycoproteins in human T-cell mediation of leukocyte adherence inhibition to extracts of autologous cancer.人类T细胞介导白细胞对自体癌提取物黏附抑制中的T8和T3表面糖蛋白
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Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity.与自体黑色素瘤细胞反应的克隆化人细胞毒性T淋巴细胞（CTL）系。I. 体外生成、分离及表型和特异性分析。
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Eur J Immunol. 1985 Aug;15(8):841-4. doi: 10.1002/eji.1830150819.

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