人类T淋巴细胞上抗原受体的描绘。
The delineation of antigen receptors on human T lymphocytes.
作者信息
Reinherz E L, Meuer S C, Schlossman S F
机构信息
The Division of Tumor Immunology, Sidney Farber Cancer Institute and the Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Immunol Today. 1983 Jan;4(1):5-8. doi: 10.1016/0167-5699(83)90094-4.
Monoclonal antibodies have identified several surface molecules involved in target cell recognition by cytotoxic human T cells. In this article it is proposed that T cells have two recognition units: a complex composed of the T3 molecule and a clonally unique glycoprotein which binds antigen associated with polymorphic MHC gene product; and the T4 or T8 molecule which binds to a constant region of an MHC gene product.
单克隆抗体已识别出几种参与细胞毒性人T细胞识别靶细胞的表面分子。本文提出，T细胞有两个识别单位：一个由T3分子和一种克隆独特的糖蛋白组成的复合物，该糖蛋白结合与多态性MHC基因产物相关的抗原；以及与MHC基因产物恒定区结合的T4或T8分子。
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