Silberstein D S, David J R
Department of Medicine, Harvard Medical School, Department of Rheumatology and Immunology, Brigham and Women's Hospital, USA.
Department of Medicine, Harvard Medical School, Department of Rheumatology and Immunology, Brigham and Women's Hospital, USA; Department of Tropical Public Health, Harvard School of Public Health, Boston, MA 02115, USA.
Immunol Today. 1987;8(12):380-5. doi: 10.1016/0167-5699(87)90214-3.
The factors responsible for eosinophil regulation fall broadly into three categories - endogenous chemotactic molecules, factors derived from invading organisms and the cytokines. As David Silberstein and John David reveal, cytokines appear to prime eosinophils for a cytotoxic response to invading organisms. While it seems unlikely that there is a common mechanism for this enhancement of cytotoxicity (and the concomitant inflammation at the site of challenge), much effort is being expanded in order to determine the relationships between the less well characterized eosinophil-stimulating activities and their modes of action.
负责嗜酸性粒细胞调节的因素大致可分为三类——内源性趋化分子、入侵生物体衍生的因子和细胞因子。正如大卫·西尔伯斯坦和约翰·大卫所揭示的，细胞因子似乎使嗜酸性粒细胞对入侵生物体产生细胞毒性反应。虽然这种细胞毒性增强（以及攻击部位随之而来的炎症）不太可能存在共同机制，但人们正在付出大量努力，以确定特征不太明确的嗜酸性粒细胞刺激活性与其作用方式之间的关系。
