Keller N, Møgelvang J, Saunamäki K, Fritz-Hansen P, Sykulski R, Henriksen O
Department of Medicine, Hvidovre Hospital, Denmark.
J Intern Med. 1989 Sep;226(3):195-200. doi: 10.1111/j.1365-2796.1989.tb01379.x.
Atrial natriuretic factor (ANF) was determined in pulmonary and systemic arterial plasma during diagnostic left and right heart catheterization in twenty-three patients. In twenty of these patients ANF was subsequently measured in systemic arterial plasma during nuclear magnetic resonance (NMR) imaging of the heart with computation of left heart chamber volumes and left ventricular mass. Left ventricular end-diastolic pressure was the strongest independent predictor of pulmonary arterial plasma ANF, whereas cardiac index best predicted aortic plasma ANF. Both pulmonary and aortic plasma ANF correlated with systolic and diastolic pulmonary arterial pressure, left ventricular end-diastolic pressure and cardiac index. Left atrial volume index and left ventricular mass index did not correlate with systemic arterial plasma ANF whereas a positive linear correlation between left ventricular end-diastolic volume index and ANF could be demonstrated (r = 0.61, P less than 0.01). Left ventricular end-diastolic volume index was the most important independent predictor of systemic arterial plasma ANF. Systemic arterial plasma ANF might be a simple marker of left ventricular dilatation in patients with heart disease.
在对23例患者进行诊断性左右心导管插入术期间，测定了肺循环和体循环动脉血浆中的心房利钠因子（ANF）。其中20例患者随后在心脏核磁共振成像（NMR）期间测定了体循环动脉血浆中的ANF，并计算了左心腔容积和左心室质量。左心室舒张末期压力是肺动脉血浆ANF最强的独立预测因子，而心脏指数是主动脉血浆ANF的最佳预测因子。肺循环和主动脉血浆ANF均与收缩期和舒张期肺动脉压、左心室舒张末期压力及心脏指数相关。左心房容积指数和左心室质量指数与体循环动脉血浆ANF无相关性，而左心室舒张末期容积指数与ANF之间呈正线性相关（r = 0.61，P < 0.01）。左心室舒张末期容积指数是体循环动脉血浆ANF最重要的独立预测因子。体循环动脉血浆ANF可能是心脏病患者左心室扩张的一个简单标志物。
