Peddi Sandeep, Ram Rapur, Kataru Sudheer Reddy, Chennu Krishna Kishore, Nandyala Rukumangadha, Kottu Radhika, Kumar V Siva
Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
Department of Medical Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
Hemodial Int. 2015 Jul;19(3):E12-5. doi: 10.1111/hdi.12229. Epub 2014 Oct 7.
Mantle cell lymphoma is a rare form of B-cell lymphoma. We present a 54-year-old gentleman with mantle cell lymphoma. It was diagnosed based on the demonstration of B-cell antigens CD20 and CD5. It was further confirmed by demonstration of overexpression of cyclin D1 on these atypical lymphocytes in the immunohistochemical staining. He also had acute renal failure and proteinuria. Renal biopsy revealed crescents and lymphomatous infiltration of tubulointerstitium. The presence of infiltrating cells with similar markers in both the lymph node and the kidney confirmed the infiltration of kidney with lymphomatous cells. Our present patient, after a thorough literature search, is found to be the second one with a glomerular lesion and tubulointerstitial infiltration by malignant lymphoma cells.
套细胞淋巴瘤是一种罕见的B细胞淋巴瘤。我们报告一位54岁患有套细胞淋巴瘤的男性。其诊断基于B细胞抗原CD20和CD5的检测。免疫组化染色显示这些非典型淋巴细胞中细胞周期蛋白D1过表达，进一步证实了诊断。他还患有急性肾衰竭和蛋白尿。肾活检显示有新月体形成以及肾小管间质的淋巴瘤浸润。在淋巴结和肾脏中均发现具有相似标志物的浸润细胞，证实了淋巴瘤细胞对肾脏的浸润。经全面文献检索，我们目前的这位患者是第二例出现肾小球病变以及恶性淋巴瘤细胞肾小管间质浸润的病例。
