基因组编辑：一种用于研究和治疗的工具：利用基因组编辑实现对分子诊断中变异体的功能理解。 - Suppr

Suppr

超能文献

Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing.

作者信息

Tsai Shengdar Q, Iafrate A John, Joung J Keith

机构信息

Department of Pathology, Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

出版信息

Nat Med. 2014 Oct;20(10):1103-4. doi: 10.1038/nm.3722.

DOI:10.1038/nm.3722

PMID:25295940

Abstract

摘要

相似文献

Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing.

Nat Med. 2014 Oct;20(10):1103-4. doi: 10.1038/nm.3722.

Genome editing as a tool toward better functional understanding of variants identified by next-generation sequencing.

Clin Chem. 2015 Mar;61(3):564-5. doi: 10.1373/clinchem.2014.235663.

The Cpf1 CRISPR-Cas protein expands genome-editing tools.

Genome Biol. 2015 Nov 17;16:251. doi: 10.1186/s13059-015-0824-9.

CRISPR/Cas9-mediated genome editing: From basic research to translational medicine.

J Cell Mol Med. 2020 Apr;24(7):3766-3778. doi: 10.1111/jcmm.14916. Epub 2020 Feb 25.

The New RNA-Editing Era - Ethical Considerations.

Trends Genet. 2021 Aug;37(8):685-687. doi: 10.1016/j.tig.2021.04.013. Epub 2021 May 8.

Transgene-free genome editing in Caenorhabditis elegans using CRISPR-Cas.

Genetics. 2013 Nov;195(3):1167-71. doi: 10.1534/genetics.113.155879. Epub 2013 Aug 26.

Genome editing: progress and challenges for medical applications.

Genome Med. 2016 Nov 15;8(1):120. doi: 10.1186/s13073-016-0378-9.

Plasmid-free CRISPR/Cas9 genome editing in Plasmodium falciparum confirms mutations conferring resistance to the dihydroisoquinolone clinical candidate SJ733.

PLoS One. 2017 May 22;12(5):e0178163. doi: 10.1371/journal.pone.0178163. eCollection 2017.

CRISPR/Cas9 Platforms for Genome Editing in Plants: Developments and Applications.

Mol Plant. 2016 Jul 6;9(7):961-74. doi: 10.1016/j.molp.2016.04.009. Epub 2016 Apr 20.

Harnessing Type I and Type III CRISPR-Cas systems for genome editing.

Nucleic Acids Res. 2016 Feb 29;44(4):e34. doi: 10.1093/nar/gkv1044. Epub 2015 Oct 13.

引用本文的文献

The post-genomic era of biological network alignment.

EURASIP J Bioinform Syst Biol. 2015 Jun 4;2015:3. doi: 10.1186/s13637-015-0022-9. eCollection 2015 Dec.

WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system.

Genome Biol. 2015 Nov 2;16:218. doi: 10.1186/s13059-015-0784-0.

Genome editing technologies: defining a path to clinic.

Mol Ther. 2015 May;23(5):796-806. doi: 10.1038/mt.2015.54.

本文引用的文献

Optimized cell transplantation using adult rag2 mutant zebrafish.

Nat Methods. 2014 Aug;11(8):821-4. doi: 10.1038/nmeth.3031. Epub 2014 Jul 20.

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.

Nat Biotechnol. 2014 Sep;32(9):941-6. doi: 10.1038/nbt.2951. Epub 2014 Jun 22.

DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells.

Nat Chem Biol. 2014 Aug;10(8):623-5. doi: 10.1038/nchembio.1550. Epub 2014 Jun 15.

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing.

Nat Biotechnol. 2014 Jun;32(6):569-76. doi: 10.1038/nbt.2908. Epub 2014 Apr 25.

Standardized decision support in next generation sequencing reports of somatic cancer variants.

Mol Oncol. 2014 Jul;8(5):859-73. doi: 10.1016/j.molonc.2014.03.021. Epub 2014 Apr 4.

CRISPR-Cas systems for editing, regulating and targeting genomes.

Nat Biotechnol. 2014 Apr;32(4):347-55. doi: 10.1038/nbt.2842. Epub 2014 Mar 2.

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.

Nat Biotechnol. 2013 Sep;31(9):822-6. doi: 10.1038/nbt.2623. Epub 2013 Jun 23.

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.

Cell. 2013 May 9;153(4):910-8. doi: 10.1016/j.cell.2013.04.025. Epub 2013 May 2.

A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.

Science. 2012 Aug 17;337(6096):816-21. doi: 10.1126/science.1225829. Epub 2012 Jun 28.

A method and server for predicting damaging missense mutations.

Nat Methods. 2010 Apr;7(4):248-9. doi: 10.1038/nmeth0410-248.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

相似文献

Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing.

Nat Med. 2014 Oct;20(10):1103-4. doi: 10.1038/nm.3722.

Genome editing as a tool toward better functional understanding of variants identified by next-generation sequencing.

Clin Chem. 2015 Mar;61(3):564-5. doi: 10.1373/clinchem.2014.235663.

The Cpf1 CRISPR-Cas protein expands genome-editing tools.

Genome Biol. 2015 Nov 17;16:251. doi: 10.1186/s13059-015-0824-9.

CRISPR/Cas9-mediated genome editing: From basic research to translational medicine.

J Cell Mol Med. 2020 Apr;24(7):3766-3778. doi: 10.1111/jcmm.14916. Epub 2020 Feb 25.

The New RNA-Editing Era - Ethical Considerations.

Trends Genet. 2021 Aug;37(8):685-687. doi: 10.1016/j.tig.2021.04.013. Epub 2021 May 8.

Transgene-free genome editing in Caenorhabditis elegans using CRISPR-Cas.

Genetics. 2013 Nov;195(3):1167-71. doi: 10.1534/genetics.113.155879. Epub 2013 Aug 26.

Genome editing: progress and challenges for medical applications.

Genome Med. 2016 Nov 15;8(1):120. doi: 10.1186/s13073-016-0378-9.

Plasmid-free CRISPR/Cas9 genome editing in Plasmodium falciparum confirms mutations conferring resistance to the dihydroisoquinolone clinical candidate SJ733.

PLoS One. 2017 May 22;12(5):e0178163. doi: 10.1371/journal.pone.0178163. eCollection 2017.

CRISPR/Cas9 Platforms for Genome Editing in Plants: Developments and Applications.

Mol Plant. 2016 Jul 6;9(7):961-74. doi: 10.1016/j.molp.2016.04.009. Epub 2016 Apr 20.

Harnessing Type I and Type III CRISPR-Cas systems for genome editing.

Nucleic Acids Res. 2016 Feb 29;44(4):e34. doi: 10.1093/nar/gkv1044. Epub 2015 Oct 13.

引用本文的文献

The post-genomic era of biological network alignment.

EURASIP J Bioinform Syst Biol. 2015 Jun 4;2015:3. doi: 10.1186/s13637-015-0022-9. eCollection 2015 Dec.

WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system.

Genome Biol. 2015 Nov 2;16:218. doi: 10.1186/s13059-015-0784-0.

Genome editing technologies: defining a path to clinic.

Mol Ther. 2015 May;23(5):796-806. doi: 10.1038/mt.2015.54.

本文引用的文献

Optimized cell transplantation using adult rag2 mutant zebrafish.

Nat Methods. 2014 Aug;11(8):821-4. doi: 10.1038/nmeth.3031. Epub 2014 Jul 20.

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.

Nat Biotechnol. 2014 Sep;32(9):941-6. doi: 10.1038/nbt.2951. Epub 2014 Jun 22.

DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells.

Nat Chem Biol. 2014 Aug;10(8):623-5. doi: 10.1038/nchembio.1550. Epub 2014 Jun 15.

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing.

Nat Biotechnol. 2014 Jun;32(6):569-76. doi: 10.1038/nbt.2908. Epub 2014 Apr 25.

Standardized decision support in next generation sequencing reports of somatic cancer variants.

Mol Oncol. 2014 Jul;8(5):859-73. doi: 10.1016/j.molonc.2014.03.021. Epub 2014 Apr 4.

CRISPR-Cas systems for editing, regulating and targeting genomes.

Nat Biotechnol. 2014 Apr;32(4):347-55. doi: 10.1038/nbt.2842. Epub 2014 Mar 2.

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.

Nat Biotechnol. 2013 Sep;31(9):822-6. doi: 10.1038/nbt.2623. Epub 2013 Jun 23.

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.

Cell. 2013 May 9;153(4):910-8. doi: 10.1016/j.cell.2013.04.025. Epub 2013 May 2.

A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.

Science. 2012 Aug 17;337(6096):816-21. doi: 10.1126/science.1225829. Epub 2012 Jun 28.

A method and server for predicting damaging missense mutations.

Nat Methods. 2010 Apr;7(4):248-9. doi: 10.1038/nmeth0410-248.