Wilson Dan, Moehlis Jeff
Department of Mechanical Engineering, University of California, Santa Barbara, California.
Department of Mechanical Engineering, University of California, Santa Barbara, California.
Biophys J. 2014 Oct 7;107(7):1744-55. doi: 10.1016/j.bpj.2014.08.013.
We develop an approach to find an energy-optimal stimulus that entrains an ensemble of uncertain, uncoupled limit cycle oscillators. Furthermore, when entrainment occurs, the phase shift between oscillators is constrained to be less than a predetermined amount. This approach is illustrated for a model of Drosophila circadian activity, for which it performs better than a standard 24-h light-dark cycle. Because this method explicitly accounts for uncertainty in a given system and only requires information that is experimentally obtainable, it is well suited for experimental implementation and could ultimately represent what is believed to be a novel treatment for patients suffering from advanced/delayed sleep-phase syndrome.
我们开发了一种方法来找到能量最优刺激，该刺激可驱动一组不确定的、未耦合的极限环振荡器。此外，当发生同步时，振荡器之间的相移被限制在小于预定值的范围内。这种方法在果蝇昼夜活动模型中得到了说明，在该模型中它比标准的24小时明暗周期表现更好。由于该方法明确考虑了给定系统中的不确定性，并且只需要实验可获得的信息，因此它非常适合实验实施，最终可能代表一种被认为是治疗晚期/延迟睡眠相位综合征患者的新方法。
