Amdekar Sarika, Singh Vinod, Kumar Avnish, Sharma Poonam, Singh Rambir
Department of Microbiology, Barkatullah University, Hoshangabad Road Habibganj, Bhopal, 462026 Madhya Pradesh India.
Department of Biotechnology, Dr. B. R. Ambedkar University, Agra, 282004 India.
Indian J Clin Biochem. 2014 Oct;29(4):471-8. doi: 10.1007/s12291-013-0396-y. Epub 2013 Nov 27.
Arthritis is an inflammatory disease of joints. Exact etiology of the disease is not understood yet; but histopathological examination of vital organs like liver, kidney, ovary and knee joint can anticipate immune mediated damage. In this study, Lactobacillus acidophilus was administered orally by both prophylactic and curative protocol in freund's complete adjuvant induced arthritic rats. Indomethacin was used as standard anti-arthritic drug. Histopathology of liver, kidney, ovary and right hind knee joint were done. Cytokine concentrations were determined by using ELISA. Effects shown by L. acidophilus were comparable with indomethacin. Histopathological analysis of liver, kidney, ovaries and knee joints of L. acidophilus fed groups revealed significantly less damage as compared with other counterparts. Lactobacillus treatment has down-regulated pro-inflammatory level and up-regulated anti-inflammatory cytokines level in serum samples. L. acidophilus managed organs damage associated with arthritis. It has significantly down regulated the pro-inflammatory cytokines.
关节炎是一种关节炎症性疾病。该疾病的确切病因尚不清楚；但对肝脏、肾脏、卵巢和膝关节等重要器官进行组织病理学检查可以预测免疫介导的损伤。在本研究中，通过预防性和治疗性方案对弗氏完全佐剂诱导的关节炎大鼠口服嗜酸乳杆菌。吲哚美辛用作标准抗关节炎药物。对肝脏、肾脏、卵巢和右后膝关节进行了组织病理学检查。通过酶联免疫吸附测定法测定细胞因子浓度。嗜酸乳杆菌显示出的效果与吲哚美辛相当。与其他对照组相比，喂食嗜酸乳杆菌组的肝脏、肾脏、卵巢和膝关节的组织病理学分析显示损伤明显更少。嗜酸乳杆菌治疗降低了血清样本中的促炎水平并上调了抗炎细胞因子水平。嗜酸乳杆菌控制了与关节炎相关的器官损伤。它显著下调了促炎细胞因子。
