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陈年大蒜提取物可保护顺铂处理的成年雄性大鼠免受氧化应激和肾脏变化的影响。

Aged garlic extract protects against oxidative stress and renal changes in cisplatin-treated adult male rats.

作者信息

Nasr Ashraf Y, Saleh Hamid Am

机构信息

Anatomy Department, Faculty of Medicine, King Abdulaziz University, P.O. Box 80205, Jeddah, 21589 Kingdom of Saudi Arabia ; Anatomy Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Anatomy Department, Faculty of Medicine, King Abdulaziz University, P.O. Box 80205, Jeddah, 21589 Kingdom of Saudi Arabia.

出版信息

Cancer Cell Int. 2014 Sep 28;14(1):92. doi: 10.1186/s12935-014-0092-x. eCollection 2014.

DOI:10.1186/s12935-014-0092-x
PMID:25298749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4189163/
Abstract

BACKGROUND

Cisplatin (CP) is one of the effective anticancer drugs, but it causes many side effects. Aged garlic extract (AGE) is a natural herbal product used in management of many diseases.

OBJECTIVE

This study aimed to investigate effect of AGE on CP-induced nephrotoxicity in rats.

MATERIAL AND METHODS

Four equal groups of adult male rats: control, AGE -treated (250 mg/kg, once oral dose/ 21days), CP-treated (7.5 mg/kg once i.p. on day 16th.), combined AGE and CP-treated were used. Body and kidneys weights of each rat were calculated. Serum levels of kidney biomarkers were assessed. Malondialdehyde (MDA) and reduce glutathione (GSH) levels, superoxide dismutase (SOD) and catalase (CAT) activities of renal tissues were measured as well. Renal samples from each rat were prepared for light and electron microscopic examinations.

RESULTS

Hemorrhage, glomerular atrophy, inflammatory cell infiltration, tubular necrosis and degeneration were observed in CP-treated rats. Also, a significant (P<0.001) reduction in SOD & CAT activities, GSH levels accompanied with a significant increase in serum levels of kidney biomarkers and MDA were determined in CP-treated rats compared to control group. However, most of CP-induced histomorphological, ultrastructural and biochemical changes were improved in animals pretreated with AGE.

CONCLUSION

Such renoprotective effect of AGE may be attributed to its antioxidant activity.

摘要

背景

顺铂（CP）是一种有效的抗癌药物，但会引起许多副作用。 aged大蒜提取物（AGE）是一种用于治疗多种疾病的天然草药产品。

目的

本研究旨在探讨AGE对CP诱导的大鼠肾毒性的影响。

材料与方法

将成年雄性大鼠分为四组，每组数量相等：对照组、AGE处理组（250mg/kg，口服一次/21天）、CP处理组（第16天腹腔注射一次，剂量为7.5mg/kg）、AGE与CP联合处理组。计算每只大鼠的体重和肾脏重量。评估血清中肾脏生物标志物的水平。还测量了肾组织中丙二醛（MDA）和还原型谷胱甘肽（GSH）的水平、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性。对每只大鼠的肾脏样本进行光镜和电镜检查。

结果

在CP处理的大鼠中观察到出血、肾小球萎缩、炎性细胞浸润、肾小管坏死和变性。此外，与对照组相比，CP处理的大鼠中SOD和CAT活性、GSH水平显著降低（P<0.001），同时肾脏生物标志物和MDA的血清水平显著升高。然而，在用AGE预处理的动物中，CP诱导的大多数组织形态学、超微结构和生化变化得到改善。

结论

AGE的这种肾脏保护作用可能归因于其抗氧化活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/68305f161a79/12935_2014_92_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/4f0ce318ec5e/12935_2014_92_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/c27dac3880be/12935_2014_92_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/703813e99e71/12935_2014_92_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/5aba3d96ecb9/12935_2014_92_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/541097adc863/12935_2014_92_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/f9701ebe7370/12935_2014_92_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/e11f01677e6d/12935_2014_92_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/68305f161a79/12935_2014_92_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/4f0ce318ec5e/12935_2014_92_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/c27dac3880be/12935_2014_92_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/703813e99e71/12935_2014_92_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/5aba3d96ecb9/12935_2014_92_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/541097adc863/12935_2014_92_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/f9701ebe7370/12935_2014_92_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/e11f01677e6d/12935_2014_92_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8640/4189163/68305f161a79/12935_2014_92_Fig8_HTML.jpg

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