Che J J, Shao Y X, Li G P
Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China
Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.
Genet Mol Res. 2014 Sep 26;13(3):7708-17. doi: 10.4238/2014.September.26.8.
Risk factors for premature coronary heart disease in China can be multiple; we investigated Chinese Han patients with premature coronary heart disease and a possible association with CD36 polymorphism at rs1049673, rs7755, and rs321159 sites. Outpatients were recruited according to chest X-ray coronary arteriography results; they were divided into two groups: early coronary artery lesions (premature coronary heart disease group, test group) and a control group. Coronary arteriography and laboratory blood examinations were conducted to analyze risk factors for coronary heart disease and CD36 polymorphisms. Seventy nine test and 56 control group patients were recruited. Compared with the control, the test groups had a significantly higher proportion of male patients, smoking, diabetes and metabolic syndromes, significantly higher levels of TG, LDL-C, ox-LDL, WBC, UA, FBG, and significantly lower levels of HDL-C. For rs1049673, rs7755, and rs321159 sites, patients with premature coronary heart disease have family genetic predisposition at high LDL-C level with GA, AA, and TT genotypes. Unconditional logistic regression analysis showed that gender, diabetes, high TG, LDL-C level and C carriers of rs1049673 significantly affected risk for premature coronary heart disease.
中国早发性冠心病的危险因素可能是多方面的；我们调查了中国汉族早发性冠心病患者及其与rs1049673、rs7755和rs321159位点CD36基因多态性的可能关联。根据胸部X线冠状动脉造影结果招募门诊患者；他们被分为两组：早期冠状动脉病变（早发性冠心病组，试验组）和对照组。进行冠状动脉造影和实验室血液检查以分析冠心病危险因素和CD36基因多态性。招募了79例试验组患者和56例对照组患者。与对照组相比，试验组男性患者、吸烟、糖尿病和代谢综合征的比例显著更高，TG、LDL-C、氧化型LDL、白细胞、尿酸、空腹血糖水平显著更高，而HDL-C水平显著更低。对于rs1049673、rs7755和rs321159位点，早发性冠心病患者在高LDL-C水平时具有GA、AA和TT基因型的家族遗传易感性。非条件逻辑回归分析表明，性别、糖尿病、高TG、LDL-C水平以及rs1049673的C携带者显著影响早发性冠心病的风险。
