Gong Qiu-Wen, Liao Mao-Fan, Liu Liang, Xiong Xiao-Yi, Zhang Qin, Zhong Qi, Zhou Kai, Yang Yuan-Rui, Meng Zhao-You, Gong Chang-Xiong, Xu Rui, Yang Qing-Wu
Department of Neurology, Xinqiao Hospital, The Third Military Medical University, No. 183, Xinqiao Main Street, Shapingba District, Chongqing 400037, China.
Biomed Res Int. 2017;2017:5352071. doi: 10.1155/2017/5352071. Epub 2017 Jul 19.
The CD36 gene encodes a membrane glycoprotein (type B scavenger receptor, SR-B2) that plays a crucial role in lipid sensing, innate immunity, atherogenesis, and glycolipid metabolism. In this study, we aimed to investigate the association between CD36 gene polymorphisms and intracerebral hemorrhage (ICH) in a Han Chinese population. We performed genotype and allele analyses for eleven single nucleotide polymorphisms (SNPs) of CD36 in a case-controlled study involving 292 ICH patients and 298 control participants. Eleven SNPs were genotyped by the Improved Multiple Ligase Detection Reaction (iMLDR) method. The results indicated that the SNP rs1194182 values were significantly different between ICH group and control group in a dominant model after adjusting for confounding factors. The subgroup analysis conducted for rs1194182 showed that the allele G frequencies were significantly different between ICH patients and controls in hypertension group via a dominant model. We then analyzed the rs1194182 genotype distributions among different groups of the serum lipid groups, including BMI, TC, TG, HDL, and LDL. However, no significant differences were found in the analysis of other subgroups. Taken together, these findings indicate that rs1194182 polymorphism in the CD36 gene was associated with ICH, and genotype GG could be an independent predictor.
CD36基因编码一种膜糖蛋白（B型清道夫受体，SR - B2），其在脂质感知、天然免疫、动脉粥样硬化形成以及糖脂代谢中发挥关键作用。在本研究中，我们旨在调查汉族人群中CD36基因多态性与脑出血（ICH）之间的关联。在一项涉及292例ICH患者和298例对照参与者的病例对照研究中，我们对CD36的11个单核苷酸多态性（SNP）进行了基因型和等位基因分析。采用改良多重连接酶检测反应（iMLDR）方法对11个SNP进行基因分型。结果表明，在调整混杂因素后，SNP rs1194182的值在ICH组和对照组之间的显性模型中存在显著差异。对rs1194182进行的亚组分析表明，在高血压组中，ICH患者和对照组之间通过显性模型的等位基因G频率存在显著差异。然后，我们分析了rs1194182基因型在不同血清脂质组中的分布，包括BMI、TC、TG、HDL和LDL。然而，在其他亚组分析中未发现显著差异。综上所述，这些发现表明CD36基因中的rs1194182多态性与ICH相关，基因型GG可能是一个独立的预测因子。
