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致动脉粥样硬化风险因素与听力阈值

Atherogenic risk factors and hearing thresholds.

作者信息

Frederiksen Thomas Winther, Ramlau-Hansen Cecilia Høst, Stokholm Zara Ann, Brødsgaard Grynderup Matias, Hansen Åse Marie, Lund Søren Peter, Medom Vestergaard Jesper, Kristiansen Jesper, Bonde Jens Peter, Kolstad Henrik Albert

机构信息

Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark.

出版信息

Audiol Neurootol. 2014;19(5):310-8. doi: 10.1159/000365439. Epub 2014 Oct 9.

Abstract

The objective of this study was to evaluate the influence of atherogenic risk factors on hearing thresholds. In a cross-sectional study we analyzed data from a Danish survey in 2009-2010 on physical and psychological working conditions. The study included 576 white- and blue-collar workers from children's day care units, financial services and 10 manufacturing trades. Associations between atherogenic risk factors (blood lipids, glycosylated hemoglobin, smoking habits, body mass index (BMI), and ambulatory blood pressure) and hearing thresholds were analyzed using multiple linear regression models. Adjusted results suggested associations between smoking, high BMI and triglyceride level and low high-density lipoprotein level and increased low-frequency hearing thresholds (average of pure-tone hearing thresholds at 0.25, 0.5 and 1 kHz). Furthermore, an increasing load of atherogenic risk factors seemed associated with increased low-frequency hearing thresholds, but only at a borderline level of statistical significance. Associations were generally strongest with hearing levels of the worst hearing ear. We found no statistically significant associations between atherogenic risk factors and high-frequency hearing thresholds (average of pure-tone hearing thresholds at 4, 6 and 8 kHz).

摘要

本研究的目的是评估动脉粥样硬化风险因素对听力阈值的影响。在一项横断面研究中,我们分析了2009 - 2010年丹麦一项关于身体和心理工作条件的调查数据。该研究纳入了来自儿童日托机构、金融服务行业以及10个制造业行业的576名白领和蓝领工人。使用多元线性回归模型分析动脉粥样硬化风险因素(血脂、糖化血红蛋白、吸烟习惯、体重指数(BMI)和动态血压)与听力阈值之间的关联。校正后的结果表明,吸烟、高BMI、甘油三酯水平升高以及高密度脂蛋白水平降低与低频听力阈值升高(0.25、0.5和1千赫处纯音听力阈值的平均值)之间存在关联。此外,动脉粥样硬化风险因素负荷增加似乎与低频听力阈值升高有关,但仅处于统计学意义的临界水平。这些关联通常在听力最差耳朵的听力水平上最为明显。我们发现动脉粥样硬化风险因素与高频听力阈值(4、6和8千赫处纯音听力阈值的平均值)之间无统计学意义的关联。

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