重组白细胞介素4抑制人单核细胞产生γ干扰素。
Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells.
作者信息
Peleman R, Wu J, Fargeas C, Delespesse G
机构信息
Notre-Dame Hospital Research Center, University of Montreal, Quebec, Canada.
出版信息
J Exp Med. 1989 Nov 1;170(5):1751-6. doi: 10.1084/jem.170.5.1751.
Abstract
rIL-4 inhibits the production of IFN-gamma by PBMC stimulated with mitogens or allogeneic cells. The suppression is observed at the protein and at the mRNA level; it is dose and time dependent, and it is abolished by a neutralizing mAb to IL-4. It is suggested that the balance between the production of IL-4 and IFN-gamma may be significantly influenced by the chronological order of activation of their respective gene.
摘要
重组白细胞介素-4抑制有丝分裂原或同种异体细胞刺激的外周血单核细胞产生γ-干扰素。在蛋白质和mRNA水平均观察到这种抑制作用；它呈剂量和时间依赖性，并且可被抗白细胞介素-4的中和单克隆抗体消除。提示白细胞介素-4和γ-干扰素产生之间的平衡可能受其各自基因激活时间顺序的显著影响。
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