Kohan Gustavo, Ocampo Carlos G, Zandalazini Hugo I, Klappenbach Roberto, Yazyi Federico, Ditulio Ornella, Coturel Adelina, Canullán Carlos, Porras Luis T Chiappetta, Rodriguez Juan Alvarez
Department of Surgery, Hospital Cosme Argerich, University of Buenos Aires, José Juan Biedma 773, CABA, Buenos Aires, Argentina,
Surg Endosc. 2015 Jul;29(7):1970-5. doi: 10.1007/s00464-014-3894-y. Epub 2014 Oct 11.
Approximately 80% of patients with pancreatic cancer are not candidates for curative resection at the time of diagnosis. The objective of this study is to show that although endoscopic treatment is the standard palliation, surgical laparoscopic treatment is both feasible and effective for these patients.
Preoperative resectability was evaluated by dynamic contrast-enhanced computed tomography scans. Endoscopic palliation was the first choice for patients with metastatic disease and for patients with locally advanced pancreatic cancer with bad performance status. Laparoscopic surgical palliation was indicated for patients with jaundice and locally advanced pancreatic cancer (elective palliation) and for patients with jaundice with metastatic disease and failure in the endoscopic/percutaneous treatment (necessary palliation). Elective palliation consisted of Roux-en-Y hepaticojejunostomy and gastrojejunostomy and necessary palliation consisted of laparoscopic hepaticojejunostomy alone.
A total of 48 patients received laparoscopic surgical palliation. Morbidity rate was 33.3% and mortality was 2.08%. There was no need for late surgeries in any of the patients.
Surgical laparoscopic palliation is a feasible treatment option for locally advanced pancreatic cancer. Even though metallic stents are still the best palliation method for patients with systemic disease, if stents fail, the laparoscopic approach is a viable treatment.
约80%的胰腺癌患者在确诊时不适合进行根治性切除。本研究的目的是表明,尽管内镜治疗是标准的姑息治疗方法,但手术腹腔镜治疗对于这些患者而言既可行又有效。
通过动态对比增强计算机断层扫描评估术前可切除性。内镜姑息治疗是转移性疾病患者以及全身状况较差的局部晚期胰腺癌患者的首选。腹腔镜手术姑息治疗适用于黄疸和局部晚期胰腺癌患者(选择性姑息治疗)以及黄疸伴转移性疾病且内镜/经皮治疗失败的患者(必要姑息治疗)。选择性姑息治疗包括Roux-en-Y肝空肠吻合术和胃空肠吻合术,必要姑息治疗仅包括腹腔镜肝空肠吻合术。
共有48例患者接受了腹腔镜手术姑息治疗。发病率为33.3%,死亡率为2.08%。所有患者均无需进行二期手术。
手术腹腔镜姑息治疗是局部晚期胰腺癌的一种可行治疗选择。尽管金属支架仍是全身性疾病患者的最佳姑息治疗方法,但如果支架治疗失败,腹腔镜手术是一种可行的治疗方法。