Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University Schools of Medicine and Informatics, Indianapolis, IN 46202, United States.
Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, TX 77843, United States.
Semin Cell Dev Biol. 2015 Jan;37:44-55. doi: 10.1016/j.semcdb.2014.09.025. Epub 2014 Oct 13.
Intrinsically disordered proteins (IDPs) and IDP regions lack stable tertiary structure yet carry out numerous biological functions, especially those associated with signaling, transcription regulation, DNA condensation, cell division, and cellular differentiation. Both post-translational modifications (PTMs) and alternative splicing (AS) expand the functional repertoire of IDPs. Here we propose that an "IDP-based developmental toolkit," which is comprised of IDP regions, PTMs, especially multiple PTMs, within these IDP regions, and AS events within segments of pre-mRNA that code for these same IDP regions, allows functional diversification and environmental responsiveness for molecules that direct the development of complex metazoans.
无定形蛋白质（IDPs）和 IDP 区域缺乏稳定的三级结构，但却执行着许多生物功能，特别是那些与信号转导、转录调控、DNA 凝聚、细胞分裂和细胞分化相关的功能。翻译后修饰（PTMs）和选择性剪接（AS）都扩展了 IDP 的功能范围。在这里，我们提出了一个“基于 IDP 的发育工具包”，它由 IDP 区域、这些 IDP 区域内的 PTMs（特别是多种 PTMs）以及编码这些相同 IDP 区域的前体 mRNA 片段内的 AS 事件组成，为指导复杂后生动物发育的分子提供了功能多样化和环境响应能力。
