Domingos Pedro Rauel Cândido, da Silva Pinto Ana Cristina, dos Santos Joselita Maria Mendes, Rafael Míriam Silva
Post-Graduation Program in Genetics, Conservation and Evolutionary Biology/Instituto Nacional de Pesquisas da Amazônia - INPA, Brazil.
Laboratory of Vectors of Malaria and Dengue/CPCS/INPA, Manaus, AM, Brazil.
Mutat Res Genet Toxicol Environ Mutagen. 2014 Sep 15;772:42-54. doi: 10.1016/j.mrgentox.2014.07.008. Epub 2014 Aug 2.
The effects of two semi-synthetic dillapiole derivatives, ethyl-ether dillapiole and n-butyl ether dillapiole, on eggs and larvae of Aedes aegypti were studied in view of the need for expansion and renovation of strategic action to control this mosquito - the vector of Dengue virus -, which currently shows a high resistance to chemical insecticides. Eggs and third-instar larvae of A. aegypti that had been exposed to different concentrations of these two compounds showed toxicity and susceptibility, with 100% mortality. Classical cytogenetic assays showed genotoxicity caused by the two compounds in A. aegypti from the cumulative effect of nuclear abnormalities, indicating that these derivatives may be potential alternatives to control A. aegypti.
鉴于控制埃及伊蚊（登革热病毒的传播媒介）的战略行动需要扩展和革新，而目前该蚊虫对化学杀虫剂表现出高度抗性，因此研究了两种半合成莳萝脑衍生物——乙醚莳萝脑和正丁醚莳萝脑——对埃及伊蚊卵和幼虫的影响。暴露于不同浓度这两种化合物的埃及伊蚊卵和三龄幼虫表现出毒性和易感性，死亡率达100%。经典细胞遗传学分析表明，这两种化合物因核异常的累积效应在埃及伊蚊中造成了遗传毒性，这表明这些衍生物可能是控制埃及伊蚊的潜在替代品。
