Dehennaut Vanessa, Leprince Dominique, Lefebvre Tony
Structural and Functional Glycobiology Unit, Lille 1 University , Villeneuve d'Ascq , France ; Institut de Biologie de Lille, Pasteur Institute of Lille, Université Lille Nord de France , Lille , France.
Institut de Biologie de Lille, Pasteur Institute of Lille, Université Lille Nord de France , Lille , France.
Front Endocrinol (Lausanne). 2014 Sep 26;5:155. doi: 10.3389/fendo.2014.00155. eCollection 2014.
There are increasing evidences that dietary components and metabolic disorders affect gene expression through epigenetic mechanisms. These observations support the notion that epigenetic reprograming-linked nutrition is connected to the etiology of metabolic diseases and cancer. During the last 5 years, accumulating data revealed that the nutrient-sensing O-GlcNAc glycosylation (O-GlcNAcylation) may be pivotal in the modulation of chromatin remodeling and in the regulation of gene expression by being part of the "histone code," and by identifying OGT (O-GlcNAc transferase) as an interacting partner of the TET family proteins of DNA hydroxylases and as a member of the polycomb group proteins. Thus, it is suggested that O-GlcNAcylation is a post-translational modification that links nutrition to epigenetic. This review summarizes recent findings about the interplay between O-GlcNAcylation and the epigenome and enlightens the contribution of the glycosylation to epigenetic reprograming.
越来越多的证据表明，饮食成分和代谢紊乱通过表观遗传机制影响基因表达。这些观察结果支持了这样一种观点，即与表观遗传重编程相关的营养与代谢疾病和癌症的病因有关。在过去5年中，越来越多的数据表明，营养感应性O-连接N-乙酰葡糖胺糖基化（O-GlcNAcylation）可能在染色质重塑的调节以及通过作为“组蛋白密码”的一部分和将OGT（O-连接N-乙酰葡糖胺转移酶）鉴定为DNA羟化酶的TET家族蛋白的相互作用伙伴以及作为多梳蛋白家族蛋白的成员来调节基因表达方面起着关键作用。因此，有人提出O-GlcNAcylation是一种将营养与表观遗传联系起来的翻译后修饰。本综述总结了关于O-GlcNAcylation与表观基因组之间相互作用的最新发现，并阐明了糖基化对表观遗传重编程的贡献。
